Determinants of patient-reported functional mobility in people with Parkinson's disease: A systematic review

Anne Marie Hanff*, Claire Pauly, Laure Pauly, Armin Rauschenberger, Anja K. Leist, Rejko Krüger, Maurice P. Zeegers, Christopher McCrum

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Information on determinants of patient-reported functional mobility is lacking but would inform the planning of healthcare, resources and strategies to promote functional mobility in people with Parkinson's disease (PD). Research question: To identify the determinants of patient-reported functional mobility of people with PD. Methods: Eligible: Randomized Controlled Trials, cohort, case-control, or cross-sectional analyses in people PD without date or setting restrictions, published in English, German, or French. Excluded: instruments with under 50 % of items measuring mobility. On August 9th 2023 we last searched Medline, CINAHL and PsychInfo. We assessed risk of bias using the mixed-methods appraisal tool. Results were synthesized by tabulating the determinants by outcomes and study designs. Results: Eleven studies published 2012–2023 were included (most in Swedish outpatient settings). Samples ranged from 9 to 255 participants. Follow-up varied from 1.5 to 36 months with attrition of 15–42 %. Heterogenic study designs complicated results synthesis. However, determinants related to environment seem to associate the strongest with patient-reported functional mobility, although determinants related to body structures and functions were most investigated. We identified disease duration, the ability to drive, caregiving, sex, age, cognitive impairment, postural instability and social participation as determinants of patient-reported functional mobility. Discussion: Methodological quality of the studies was limited. No study reported an a priori power calculation. Three studies controlled for confounders. The included studies lack representativeness of the population of people living with PD. Standardized sets of outcomes could enable more systematic research synthesis. Conclusions: Future research should focus on activities, participation and environmental factors and improve methodological quality.

Original languageEnglish
Pages (from-to)97-109
Number of pages13
JournalGait and Posture
Volume108
Early online date23 Nov 2023
DOIs
Publication statusPublished - Feb 2024

Keywords

  • Dependent ambulation
  • Mobility limitation
  • Parkinson's disease
  • Patient reported outcome measures
  • Review
  • Self report
  • Walking

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