Design of a prospective, longitudinal cohort of people living with type 1 diabetes exploring factors associated with the residual cardiovascular risk and other diabetes-related complications: The SFDT1 study

J. P. Riveline*, B. Vergés, B. Detournay, S. Picard, P. Y. Benhamou, E. Bismuth, L. Bordier, N. Jeandidier, M. Joubert, R. Roussel, A. Sola-Gazagnes, A. Bonnefond, S. Clavel, F. L. Velayoudom, J. Beltrand, H. Hanaire, P. Fontaine, C. Thivolet, H. Servy, S. TubianaS. Lion, Jean François Gautier, Etienne Larger, E. Vicaut, L. Sablone, G. Fagherazzi, E. Cosson

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Type 1 diabetes mellitus (T1DM) is associated with a high risk of cardiovascular (CV) complications, even after controlling for traditional CV risk factors. Therefore, determinants of the residual increased CV morbidity and mortality remain to be discovered. This prospective cohort of people living with T1DM in France (SFDT1) will include adults and children aged over six years living with T1DM, recruited throughout metropolitan France and overseas French departments and territories. The primary objective is to better understand the parameters associated with CV complications in T1DM. Clinical data and biobank samples will be collected during routine visits every three years. Data from connected tools, including continuous glucose monitoring, will be available during the 10-year active follow-up. Patient-reported outcomes, psychological and socioeconomic information will also be collected either at visits or through web questionnaires accessible via the internet. Additionally, access to the national health data system (Health Data Hub) will provide information on healthcare and a passive 20-year medico-administrative follow-up. Using Health Data Hub, SFDT1 participants will be compared to non-diabetic individuals matched on age, gender, and residency area. The cohort is sponsored by the French-speaking Foundation for Diabetes Research (FFRD) and aims to include 15,000 participants.

Original languageEnglish
Article number101306
Pages (from-to)101306
JournalDiabetes and Metabolism
Volume48
Issue number3
Early online date21 Nov 2021
DOIs
Publication statusPublished - May 2022
Externally publishedYes

Keywords

  • Cardiovascular risk factors
  • Cohort
  • Glucose variability
  • Hypoglycaemia
  • Macroangiopathy
  • Quality of life
  • Type 1 diabetes

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