Description and Management of Radiotherapy-Induced Long-Term Effects

Guillaume Vogin*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)


Radiation therapy (RT) is involved in about 50% of cures. However, overall, after a median follow-up of 2.3 years, 3–5% of the treated patients are estimated to suffer from late toxicity that can cause potentially serious sequelae—in absence of therapeutic deviation. These toxicities are essentially cardiovascular, renal, endocrine, and musculoskeletal but also include secondary radiation-induced malignancies. The incidence of late complications continued to increase with the duration of follow-up without reaching a plateau. These late effects are characterized by a clinical latency during which intricated cellular and tissue events take place, as described in the second section. Several patient- and treatment-related cofactors are associated with late effects occurrence including individual radiosensitivity and radiosensitive syndromes. In the fourth section, we provide a clinical description of “deterministic” late effects according to organ/tissue location and radiosensitivity with a specific emphasis on pediatrics. After reviewing the stochastic late effects, we give insights into the current management of radiotherapy-induced sequelae with curative and preventive approaches.

Original languageEnglish
Title of host publicationSurvivorship Care for Cancer Patients
Subtitle of host publicationA Clinician's Handbook
PublisherSpringer International Publishing
Number of pages29
ISBN (Electronic)9783030786489
ISBN (Print)9783030786472
Publication statusPublished - 1 Jan 2021
Externally publishedYes


  • DNA repair
  • Fibrosis
  • Individual radiosensitivity
  • Late effects
  • Radiation-induced malignancies
  • Radiotherapy
  • Toxicity


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