Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany

Tatjana Schwarz; Pinkus Tober-Lau; David Hillus; Elisa T. Helbig; Lena J. Lippert; Charlotte Thibeault; Willi Koch; Irmgard Landgraf; Janine Michel; Leon Bergfeld; Daniela Niemeyer; Barbara Mühlemann; Claudia Conrad; Chantip Dang-Heine; Stefanie Kasper; Friederike Münn; Kai Kappert; Andreas Nitsche; Rudolf Tauber; Sein Schmidt; Piotr Kopankiewicz; Harald Bias; Joachim Seybold; Christof von Kalle; Terry C. Jones; Norbert Suttorp; Christian Drosten; Leif Erik Sander; Victor M. Corman; Florian Kurth

doi:10.3201/eid2708.211145

Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany

Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T. Helbig, Lena J. Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein SchmidtPiotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C. Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander^*, Victor M. Corman^*, Florian Kurth^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

Original language	English
Pages (from-to)	2174-2178
Number of pages	5
Journal	Emerging Infectious Diseases
Volume	27
Issue number	8
DOIs	https://doi.org/10.3201/eid2708.211145
Publication status	Published - Aug 2021
Externally published	Yes

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Schwarz, T., Tober-Lau, P., Hillus, D., Helbig, E. T., Lippert, L. J., Thibeault, C., Koch, W., Landgraf, I., Michel, J., Bergfeld, L., Niemeyer, D., Mühlemann, B., Conrad, C., Dang-Heine, C., Kasper, S., Münn, F., Kappert, K., Nitsche, A., Tauber, R., ... Kurth, F. (2021). Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany. Emerging Infectious Diseases, 27(8), 2174-2178. https://doi.org/10.3201/eid2708.211145

@article{44ef3165573940009abd2634360199fe,

title = "Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany",

abstract = "We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.",

author = "Tatjana Schwarz and Pinkus Tober-Lau and David Hillus and Helbig, {Elisa T.} and Lippert, {Lena J.} and Charlotte Thibeault and Willi Koch and Irmgard Landgraf and Janine Michel and Leon Bergfeld and Daniela Niemeyer and Barbara M{\"u}hlemann and Claudia Conrad and Chantip Dang-Heine and Stefanie Kasper and Friederike M{\"u}nn and Kai Kappert and Andreas Nitsche and Rudolf Tauber and Sein Schmidt and Piotr Kopankiewicz and Harald Bias and Joachim Seybold and {von Kalle}, Christof and Jones, {Terry C.} and Norbert Suttorp and Christian Drosten and Sander, {Leif Erik} and Corman, {Victor M.} and Florian Kurth",

year = "2021",

month = aug,

doi = "10.3201/eid2708.211145",

language = "English",

volume = "27",

pages = "2174--2178",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "8",

}

Schwarz, T, Tober-Lau, P, Hillus, D, Helbig, ET, Lippert, LJ, Thibeault, C, Koch, W, Landgraf, I, Michel, J, Bergfeld, L, Niemeyer, D, Mühlemann, B, Conrad, C, Dang-Heine, C, Kasper, S, Münn, F, Kappert, K, Nitsche, A, Tauber, R, Schmidt, S, Kopankiewicz, P, Bias, H, Seybold, J, von Kalle, C, Jones, TC, Suttorp, N, Drosten, C, Sander, LE, Corman, VM & Kurth, F 2021, 'Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany', Emerging Infectious Diseases, vol. 27, no. 8, pp. 2174-2178. https://doi.org/10.3201/eid2708.211145

TY - JOUR

T1 - Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany

AU - Schwarz, Tatjana

AU - Tober-Lau, Pinkus

AU - Hillus, David

AU - Helbig, Elisa T.

AU - Lippert, Lena J.

AU - Thibeault, Charlotte

AU - Koch, Willi

AU - Landgraf, Irmgard

AU - Michel, Janine

AU - Bergfeld, Leon

AU - Niemeyer, Daniela

AU - Mühlemann, Barbara

AU - Conrad, Claudia

AU - Dang-Heine, Chantip

AU - Kasper, Stefanie

AU - Münn, Friederike

AU - Kappert, Kai

AU - Nitsche, Andreas

AU - Tauber, Rudolf

AU - Schmidt, Sein

AU - Kopankiewicz, Piotr

AU - Bias, Harald

AU - Seybold, Joachim

AU - von Kalle, Christof

AU - Jones, Terry C.

AU - Suttorp, Norbert

AU - Drosten, Christian

AU - Sander, Leif Erik

AU - Corman, Victor M.

AU - Kurth, Florian

PY - 2021/8

Y1 - 2021/8

N2 - We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

AB - We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

UR - http://www.scopus.com/inward/record.url?scp=85110563854&partnerID=8YFLogxK

U2 - 10.3201/eid2708.211145

DO - 10.3201/eid2708.211145

M3 - Review article

C2 - 34102097

AN - SCOPUS:85110563854

SN - 1080-6040

VL - 27

SP - 2174

EP - 2178

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 8

ER -

Delayed antibody and T-cell response to BNT162b2 vaccination in the elderly, Germany

Abstract

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