TY - JOUR
T1 - Dairy Intake and Parkinson's Disease
T2 - A Mendelian Randomization Study
AU - Domenighetti, Cloé
AU - Sugier, Pierre Emmanuel
AU - Ashok Kumar Sreelatha, Ashwin
AU - Schulte, Claudia
AU - Grover, Sandeep
AU - Mohamed, Océane
AU - Portugal, Berta
AU - May, Patrick
AU - Bobbili, Dheeraj R.
AU - Radivojkov-Blagojevic, Milena
AU - Lichtner, Peter
AU - Singleton, Andrew B.
AU - Hernandez, Dena G.
AU - Edsall, Connor
AU - Mellick, George D.
AU - Zimprich, Alexander
AU - Pirker, Walter
AU - Rogaeva, Ekaterina
AU - Lang, Anthony E.
AU - Koks, Sulev
AU - Taba, Pille
AU - Lesage, Suzanne
AU - Brice, Alexis
AU - Corvol, Jean Christophe
AU - Chartier-Harlin, Marie Christine
AU - Mutez, Eugénie
AU - Brockmann, Kathrin
AU - Deutschländer, Angela B.
AU - Hadjigeorgiou, Georges M.
AU - Dardiotis, Efthimos
AU - Stefanis, Leonidas
AU - Simitsi, Athina Maria
AU - Valente, Enza Maria
AU - Petrucci, Simona
AU - Duga, Stefano
AU - Straniero, Letizia
AU - Zecchinelli, Anna
AU - Pezzoli, Gianni
AU - Brighina, Laura
AU - Ferrarese, Carlo
AU - Annesi, Grazia
AU - Quattrone, Andrea
AU - Gagliardi, Monica
AU - Matsuo, Hirotaka
AU - Kawamura, Yusuke
AU - Hattori, Nobutaka
AU - Nishioka, Kenya
AU - Chung, Sun Ju
AU - Kim, Yun Joong
AU - Krüger, Rejko
AU - Elbaz, Alexis
AU - Gasser, Thomas
AU - Sharma, Manu
AU - and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium
N1 - Funding agencies: : This study used data from the Courage-PD consortium, conducted under a partnership agreement among 35 studies. The Courage-PD consortium is supported by the EU Joint Program for Neurodegenerative Disease research (JPND; https://www.neurodegenerationresearch.eu/initiatives/annual-calls-for-proposals/closed-calls/risk-factors-2012/risk-factor-call-results/courage-pd/). C.D. is the recipient of a doctoral grant from Université Paris-Saclay, France. P.M. was funded by the Fonds National de Recherche (FNR), Luxembourg, as part of the National Centre of Excellence in Research on Parkinson's Disease (NCER-PD, FNR11264123) and the DFG Research Units FOR2715 (INTER/DFG/17/11583046) and FOR2488 (INTER/DFG/19/14429377). A.B.S., D.G.H., and C.E. are funded by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949. E.R. is funded by the Canadian Consortium on Neurodegeneration in Aging. S.K. is funded by MSWA. P.T. is the recipient of an Estonian Research Council Grant PRG957. E.M.V. is funded by the Italian Ministry of Health (Ricerca Corrente 2021). S.B. and J.C. are supported by grants from the National Research Foundation of South Africa (grant number: 106052); the South African Medical Research Council (Self-Initiated Research Grant); and Stellenbosch University, South Africa; they also acknowledge the support of the NRF-DST Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; and Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town. P.P. and M.D.-F. have received funding from the Spanish Ministry of Science and Innovation (SAF2013-47939-R). K.W. and N.L.P. are funded by the Swedish Research Council, grant numbers K2002-27X-14056-02B, 521-2010-2479, 521-2013-2488, and 2017-02175. N.L.P. is funded by the National Institutes of Health, grant numbers ES10758 and AG 08724. C.R. is funded by the Märta Lundkvist Foundation, Swedish Brain Foundation, and Karolinska Institutet Research Fund. A.C.B. is funded by the Swedish Brain Foundation, Swedish Research Council, and Karolinska Institutet Research Funds. M.T. (M. Tan) is funded by the Parkinson's UK. M.S. was supported by grants from the German Research Council (DFG/SH 599/6-1), MSA Coalition, and The Michael J. Fox Foundation (USA Genetic Diversity in PD Program: GAP-India Grant ID: 17473). PG GEN sample collection was funded by the MRC and UK Medical Research Council (C.E.C. and K.E.M.). The sponsors had no role in the study design, data collection, data analysis, data interpretation, writing of the report, or decision to submit the paper for publication.
© 2022 International Parkinson and Movement Disorder Society.
PY - 2022/4
Y1 - 2022/4
N2 - Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.
AB - Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.
KW - dairy intake; Parkinson's disease; Mendelian randomization
UR - http://www.scopus.com/inward/record.url?scp=85128406510&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/34997937
U2 - 10.1002/mds.28902
DO - 10.1002/mds.28902
M3 - Article
C2 - 34997937
SN - 0885-3185
VL - 37
SP - 857
EP - 864
JO - Movement Disorders
JF - Movement Disorders
IS - 4
ER -