Cytotoxic triterpenoids from Abies recurvata

Yong Li Li; Yan Xia Gao; Xian Wen Yang; Hui Zi Jin; Ji Ye; Luke Simmons; Ning Wang; Andre Steinmetz; Wei Dong Zhang

doi:10.1016/j.phytochem.2012.05.032

Cytotoxic triterpenoids from Abies recurvata

Yong Li Li
, Yan Xia Gao
, Xian Wen Yang^*
, Hui Zi Jin
, Ji Ye
, Luke Simmons
, Ning Wang
, Andre Steinmetz
, Wei Dong Zhang

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Abstract

Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC ₅₀ value of 17.8 μg/mL.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Phytochemistry
Volume	81
DOIs	https://doi.org/10.1016/j.phytochem.2012.05.032
Publication status	Published - Sept 2012

Keywords

Abies recurvata
Cu-Ka X-ray crystallography
Cytotoxicity
Pinaceae
Triterpenoids

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10.1016/j.phytochem.2012.05.032

Cite this

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title = "Cytotoxic triterpenoids from Abies recurvata",

abstract = "Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC 50 value of 17.8 μg/mL.",

keywords = "Abies recurvata, Cu-Ka X-ray crystallography, Cytotoxicity, Pinaceae, Triterpenoids",

author = "Li, \{Yong Li\} and Gao, \{Yan Xia\} and Yang, \{Xian Wen\} and Jin, \{Hui Zi\} and Ji Ye and Luke Simmons and Ning Wang and Andre Steinmetz and Zhang, \{Wei Dong\}",

note = "Funding Information: This work was supported by the Special Program for New Drug Innovation of the Ministry of Science and Technology, China ( 2009ZX09308-005 ), the National Natural Science Foundation of China ( 41176148 , 21002110 , and 30725045 ), the Shanghai Leading Academic Discipline Project ( B906 ), and in part by the FP7 People Work Program ( FP7-People-IRSES-2008, No. 230232 ). ",

year = "2012",

month = sep,

doi = "10.1016/j.phytochem.2012.05.032",

language = "English",

volume = "81",

pages = "159--164",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Cytotoxic triterpenoids from Abies recurvata

AU - Li, Yong Li

AU - Gao, Yan Xia

AU - Yang, Xian Wen

AU - Jin, Hui Zi

AU - Ye, Ji

AU - Simmons, Luke

AU - Wang, Ning

AU - Steinmetz, Andre

AU - Zhang, Wei Dong

N1 - Funding Information: This work was supported by the Special Program for New Drug Innovation of the Ministry of Science and Technology, China ( 2009ZX09308-005 ), the National Natural Science Foundation of China ( 41176148 , 21002110 , and 30725045 ), the Shanghai Leading Academic Discipline Project ( B906 ), and in part by the FP7 People Work Program ( FP7-People-IRSES-2008, No. 230232 ).

PY - 2012/9

Y1 - 2012/9

N2 - Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC 50 value of 17.8 μg/mL.

AB - Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC 50 value of 17.8 μg/mL.

KW - Abies recurvata

KW - Cu-Ka X-ray crystallography

KW - Cytotoxicity

KW - Pinaceae

KW - Triterpenoids

UR - https://www.scopus.com/pages/publications/84864775668

U2 - 10.1016/j.phytochem.2012.05.032

DO - 10.1016/j.phytochem.2012.05.032

M3 - Article

C2 - 22749257

AN - SCOPUS:84864775668

SN - 0031-9422

VL - 81

SP - 159

EP - 164

JO - Phytochemistry

JF - Phytochemistry

ER -

Cytotoxic triterpenoids from Abies recurvata

Abstract

Keywords

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