Cytotoxic triterpenoids from Abies recurvata

Yong Li Li, Yan Xia Gao, Xian Wen Yang*, Hui Zi Jin, Ji Ye, Luke Simmons, Ning Wang, Andre Steinmetz, Wei Dong Zhang

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC 50 value of 17.8 μg/mL.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalPhytochemistry
Volume81
DOIs
Publication statusPublished - Sept 2012

Keywords

  • Abies recurvata
  • Cu-Ka X-ray crystallography
  • Cytotoxicity
  • Pinaceae
  • Triterpenoids

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