Cytotoxic T cells - Stroma interactions

Muhammad Zaeem Noman, Houssem Benlalam, Meriem Hasmim, Salem Chouaib

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

Original languageEnglish
Pages (from-to)E19-E24
JournalBulletin du Cancer
Issue number2
Publication statusPublished - Feb 2011
Externally publishedYes


  • CTLs
  • Endothelial cells
  • HIF-1α
  • Hypoxia
  • STAT3
  • Tumor cells


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