Abstract
The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.
Original language | English |
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Pages (from-to) | E19-E24 |
Journal | Bulletin du Cancer |
Volume | 98 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2011 |
Externally published | Yes |
Keywords
- CTLs
- Endothelial cells
- HIF-1α
- Hypoxia
- STAT3
- Tumor cells