Cyaneodimycin, a Bioactive Compound Isolated from the Culture of Streptomyces cyaneofuscatus Associated with Lichina confinis

Delphine Parrot, Nathalie Legrave, Laurent Intertaglia, Isabelle Rouaud, Patrick Legembre, Martin Grube, Marcelino T. Suzuki, Sophie Tomasi*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Two new compounds, cyaneodimycin (1) and cyaneomycin (2) bearing a rare methacrylate residue, were isolated from cultures of the bacterium Streptomyces cyaneofuscatus associated with the marine lichen Lichina confinis. These astonishing structures may be derived from a pyruvate biosynthetic pathway. Cyaneodimycin (1) exhibited antiproliferative properties against B16 (IC50= 27 ± 4 µm), HaCaT (IC50= 47 ± 11 µm) and Jurkat cell lines (IC50= 18.5 ± 0.5 µm). Six known compounds 3–8 with diversified structures and interesting biological properties (diketopiperazines, actinomycin, dibenzofurane or indole derivatives) were isolated jointly with compounds 1 and 2. Among them, usnic acid (8), a common lichen compound was isolated for the first time from bacteria.

Original languageEnglish
Pages (from-to)3977-3982
Number of pages6
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number23
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes

Keywords

  • Actinobacteria
  • Cytotoxicity
  • Lichens
  • Methacrylate derivatives
  • Natural products
  • Structure elucidation
  • Symbiosis

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