Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

A. Duvoix; F. Morceau; M. Schnekenburger; S. Delhalle; M. M. Galteau; M. Dicato; M. Diederich

doi:10.1196/annals.1299.071

Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

A. Duvoix
, F. Morceau
, M. Schnekenburger
, S. Delhalle
, M. M. Galteau
, M. Dicato
, M. Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH₃ interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	1010
DOIs	https://doi.org/10.1196/annals.1299.071
Publication status	Published - 2003
Externally published	Yes

Keywords

Apoptosis
Curcumin
Leukemia

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10.1196/annals.1299.071

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title = "Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat",

abstract = "Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.",

keywords = "Apoptosis, Curcumin, Leukemia",

author = "A. Duvoix and F. Morceau and M. Schnekenburger and S. Delhalle and Galteau, \{M. M.\} and M. Dicato and M. Diederich",

year = "2003",

doi = "10.1196/annals.1299.071",

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pages = "389--392",

journal = "Annals of the New York Academy of Sciences",

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TY - JOUR

T1 - Curcumin-Induced Cell Death in Two Leukemia Cell Lines

T2 - K562 and Jurkat

AU - Duvoix, A.

AU - Morceau, F.

AU - Schnekenburger, M.

AU - Delhalle, S.

AU - Galteau, M. M.

AU - Dicato, M.

AU - Diederich, M.

PY - 2003

Y1 - 2003

N2 - Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

AB - Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

KW - Apoptosis

KW - Curcumin

KW - Leukemia

UR - https://www.scopus.com/pages/publications/1342305487

U2 - 10.1196/annals.1299.071

DO - 10.1196/annals.1299.071

M3 - Article

C2 - 15033758

AN - SCOPUS:1342305487

SN - 0077-8923

VL - 1010

SP - 389

EP - 392

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

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Keywords

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