Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

A. Duvoix, F. Morceau, M. Schnekenburger, S. Delhalle, M. M. Galteau, M. Dicato, M. Diederich*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)


Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2003
Externally publishedYes


  • Apoptosis
  • Curcumin
  • Leukemia


Dive into the research topics of 'Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat'. Together they form a unique fingerprint.

Cite this