Abstract
Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared In two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were Investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.
Original language | English |
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Pages (from-to) | 389-392 |
Number of pages | 4 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1010 |
DOIs | |
Publication status | Published - 2003 |
Externally published | Yes |
Keywords
- Apoptosis
- Curcumin
- Leukemia