Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Achim Leutz; Ole Pless; Michael Lappe; Gunnar Dittmar; Elisabeth Kowenz-Leutz

doi:10.4161/trns.2.1.13510

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Achim Leutz^*, Ole Pless, Michael Lappe, Gunnar Dittmar, Elisabeth Kowenz-Leutz

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.

Original language	English
Pages (from-to)	3-8
Number of pages	6
Journal	Transcription
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/trns.2.1.13510
Publication status	Published - 2011
Externally published	Yes

Keywords

Chromatin remodeling
Differentiation
Histone code
Methylation
Post-translational modification
Signaling
Transcription

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10.4161/trns.2.1.13510

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AB - C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.

KW - Chromatin remodeling

KW - Differentiation

KW - Histone code

KW - Methylation

KW - Post-translational modification

KW - Signaling

KW - Transcription

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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Abstract

Keywords

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