Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Achim Leutz*, Ole Pless, Michael Lappe, Gunnar Dittmar, Elisabeth Kowenz-Leutz

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalTranscription
Volume2
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Chromatin remodeling
  • Differentiation
  • Histone code
  • Methylation
  • Post-translational modification
  • Signaling
  • Transcription

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