Cross-over trials in Statistics in Medicine: The first '25' years

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)


Papers on cross-over trials that have appeared in the first 25 years of Statistics in Medicine are reviewed. Papers on bioequivalence are also considered. After a brief statistical summary, individual papers are discussed under seven headings: 1. The two-stage analysis of AB/BA trials, 2. Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given.

Original languageEnglish
Pages (from-to)3430-3442
Number of pages13
JournalStatistics in Medicine
Issue number20
Publication statusPublished - 30 Oct 2006
Externally publishedYes


  • Baselines
  • Binary data
  • Bioequivalence
  • Carry-over
  • Survival analysis


Dive into the research topics of 'Cross-over trials in Statistics in Medicine: The first '25' years'. Together they form a unique fingerprint.

Cite this