Abstract
Papers on cross-over trials that have appeared in the first 25 years of Statistics in Medicine are reviewed. Papers on bioequivalence are also considered. After a brief statistical summary, individual papers are discussed under seven headings: 1. The two-stage analysis of AB/BA trials, 2. Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given.
| Original language | English |
|---|---|
| Pages (from-to) | 3430-3442 |
| Number of pages | 13 |
| Journal | Statistics in Medicine |
| Volume | 25 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 30 Oct 2006 |
| Externally published | Yes |
Keywords
- Baselines
- Binary data
- Bioequivalence
- Carry-over
- Survival analysis