Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)

Olena Tsurkalenko, Dmitry Bulaev, Marc Paul O'Sullivan, Chantal Snoeck, Soumyabrata Ghosh, Alexey Kolodkin, Basile Rommes, Piotr Gawron, Carlos Vega Moreno, Clarissa P.C. Gomes, Anne Kaysen, Jochen Ohnmacht, Valerie E. Schröder, Lukas Pavelka, Guilherme Ramos Meyers, Laure Pauly, Claire Pauly, Anne Marie Hanff, Max Meyrath, Anja LeistEstelle Sandt, Gloria A. Aguayo, Magali Perquin, Manon Gantenbein, Tamir Abdelrahman, Jochen Klucken, Venkata Satagopam, Christiane Hilger, Jonathan Turner, Michel Vaillant, Joëlle V. Fritz, Markus Ollert, Rejko Krüger, CON-VINCE consortium and the ORCHESTRA working group

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level. METHODS: A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data. RESULTS: One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards. CONCLUSION: The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research. TRIAL REGISTRATION: Trial registration number: NCT04379297, 10 April 2020.

Original languageEnglish
Article number179
Number of pages14
JournalBMC Infectious Diseases
Volume24
Issue number1
DOIs
Publication statusPublished - 9 Feb 2024

Keywords

  • Coronavirus (COVID-19)
  • Prevalence
  • Prospective cohort study
  • SARS-CoV-2

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