TY - JOUR
T1 - COST Action 'ImpARAS'
T2 - What have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium
AU - Verhoeckx, Kitty
AU - Lindholm Bøgh, Katrine
AU - Constable, Anne
AU - Epstein, Michelle M.
AU - Hoffmann Sommergruber, Karin
AU - Holzhauser, Thomas
AU - Houben, Geert
AU - Kuehn, Annette
AU - Roggen, Erwin
AU - O'Mahony, Liam
AU - Remington, Ben
AU - Crevel, René
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/5/18
Y1 - 2020/5/18
N2 - The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated allergenicity risk assessment strategy. The COST (Cooperation in Science and Technology) Action ImpARAS (Improved Allergenicity Risk Assessment Strategy), a four-year networking project, identified gaps in current allergy risk assessment, and proposed new ideas and plans for improving it. Here, we report on the lessons learned from the ImpARAS network and suggestions for future research. The safe introduction of novel and more sustainable food protein sources, while protecting humans from food allergy, calls for a multidisciplinary approach based on an improved understanding of what determines the relative allergenic potency of proteins, novel testing and assessment methodologies, harmonized decision-making criteria, and a clear ranking approach to express the allergenicity of novel product relative to that of existing known allergenic proteins: (from 'non'/to weakly and to strongly allergenic proteins).
AB - The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated allergenicity risk assessment strategy. The COST (Cooperation in Science and Technology) Action ImpARAS (Improved Allergenicity Risk Assessment Strategy), a four-year networking project, identified gaps in current allergy risk assessment, and proposed new ideas and plans for improving it. Here, we report on the lessons learned from the ImpARAS network and suggestions for future research. The safe introduction of novel and more sustainable food protein sources, while protecting humans from food allergy, calls for a multidisciplinary approach based on an improved understanding of what determines the relative allergenic potency of proteins, novel testing and assessment methodologies, harmonized decision-making criteria, and a clear ranking approach to express the allergenicity of novel product relative to that of existing known allergenic proteins: (from 'non'/to weakly and to strongly allergenic proteins).
KW - Allergy risk assessment
KW - Decision-making criteria
KW - Food allergy
KW - de novo sensitisation
UR - http://www.scopus.com/inward/record.url?scp=85085077345&partnerID=8YFLogxK
U2 - 10.1186/s13601-020-00318-x
DO - 10.1186/s13601-020-00318-x
M3 - Review article
AN - SCOPUS:85085077345
SN - 2045-7022
VL - 10
JO - Clinical and Translational Allergy
JF - Clinical and Translational Allergy
IS - 1
M1 - 13
ER -