TY - JOUR
T1 - Cortisol, but not intranasal insulin, affects the central processing of visual food cues
AU - Ferreira de Sá, Diana S.
AU - Schulz, André
AU - Streit, Fabian E.
AU - Turner, Jonathan D.
AU - Oitzl, Melly S.
AU - Blumenthal, Terry D.
AU - Schächinger, Hartmut
N1 - Funding Information:
Diana S. Ferreira de Sá is supported by a PhD fellowship SFRH/BD/73681/2010 from Fundação para a Ciência e Tecnologia , Portugal. This project was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft: DFG), grant GRK 1389/1 and the Netherlands Scientific Organization NWO , grant DN 95-420 . The funding sources had no further role in study design, collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Stress glucocorticoids and insulin are important endocrine regulators of energy homeostasis, but little is known about their central interaction on the reward-related processing of food cues. According to a balanced group design, healthy food deprived men received either 40. IU intranasal insulin (n=. 13), 30. mg oral cortisol (n=. 12), both (n=. 15), or placebo (n=. 14). Acoustic startle responsiveness was assessed during presentation of food and non-food pictures. Cortisol enhanced startle responsiveness during visual presentation of "high glycemic" food pictures, but not during presentation of neutral and pleasant non-food pictures. Insulin had no effect. Based on the "frustrative nonreward" model these results suggest that the reward value of high glycemic food items is specifically increased by cortisol.
AB - Stress glucocorticoids and insulin are important endocrine regulators of energy homeostasis, but little is known about their central interaction on the reward-related processing of food cues. According to a balanced group design, healthy food deprived men received either 40. IU intranasal insulin (n=. 13), 30. mg oral cortisol (n=. 12), both (n=. 15), or placebo (n=. 14). Acoustic startle responsiveness was assessed during presentation of food and non-food pictures. Cortisol enhanced startle responsiveness during visual presentation of "high glycemic" food pictures, but not during presentation of neutral and pleasant non-food pictures. Insulin had no effect. Based on the "frustrative nonreward" model these results suggest that the reward value of high glycemic food items is specifically increased by cortisol.
KW - Affective startle modulation
KW - Cortisol
KW - Food cues
KW - Glycemic index
KW - Intranasal insulin
UR - http://www.scopus.com/inward/record.url?scp=84908404763&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2014.09.006
DO - 10.1016/j.psyneuen.2014.09.006
M3 - Article
C2 - 25265284
AN - SCOPUS:84908404763
SN - 0306-4530
VL - 50
SP - 311
EP - 320
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -