TY - JOUR
T1 - Correlations between overexpression of sox2ot long non-coding rna and susceptibility to breast cancer
AU - Dehghani-Samani, Mina
AU - Hassanzadeh, Naiemeh
AU - Kabiri, Hamidreza
AU - Jafari, Marzieh
AU - Shahrokhi, Matineh Rahmani G.
AU - Chermahini, Maryam J.
AU - Akbari, Arvand
AU - Noshadi, Esmat
AU - Mahmoudi, Esmaeil
AU - Jusic, Amela
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Background and Objective: The SOX2OT lcnRNA has been recognized as a positive regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including esophageal, lung, and breast cancer. The objective of the present study was to investigate the correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer. Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent breast tissue samples was performed by using qRT-PCR. To evaluate the diagnostic potential of the SOX2OT lncRNA, we performed ROC curve analyses. Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a significant overexpression in comparison with the healthy group (P<0.001). Significantly, the elevated circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate breast cancer from controls with 100% of both sensitivity and specificity. Based on the Kaplan-Meier analysis, there was no significant correlation between SOX2OT lcnRNA expression and overall survival. Conclusion: The results confirmed the association between breast cancer and higher SOX2OT lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.
AB - Background and Objective: The SOX2OT lcnRNA has been recognized as a positive regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including esophageal, lung, and breast cancer. The objective of the present study was to investigate the correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer. Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent breast tissue samples was performed by using qRT-PCR. To evaluate the diagnostic potential of the SOX2OT lncRNA, we performed ROC curve analyses. Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a significant overexpression in comparison with the healthy group (P<0.001). Significantly, the elevated circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate breast cancer from controls with 100% of both sensitivity and specificity. Based on the Kaplan-Meier analysis, there was no significant correlation between SOX2OT lcnRNA expression and overall survival. Conclusion: The results confirmed the association between breast cancer and higher SOX2OT lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.
KW - Breast cancer
KW - Cancer
KW - LcnRNA
KW - Overexpression of SOX2OT
KW - QRT-PCR
KW - SOX2OT
UR - http://www.scopus.com/inward/record.url?scp=85096683907&partnerID=8YFLogxK
U2 - 10.2174/1386207323666200514075042
DO - 10.2174/1386207323666200514075042
M3 - Article
C2 - 32407264
AN - SCOPUS:85096683907
SN - 1386-2073
VL - 23
SP - 981
EP - 987
JO - Combinatorial Chemistry and High Throughput Screening
JF - Combinatorial Chemistry and High Throughput Screening
IS - 9
ER -