Abstract
Undifferentiated Friend erythroleukemic cells (FL cells) acquire membrane microviscosity ( {Mathematical expression}), in accord with the culture cell density. At low cell density {Mathematical expression} poise, whereas at confluency it increases to {Mathematical expression} poise. Concomitantly, the total number of available transferrin receptors per cell decreases by about 80% upon increase in cell density. Modulation of membrane microviscosity, by artificial alteration of the membrane cholesterol level, mediates similar modulations of the availability of the transferrin receptors. The correlation between the availability of the transferrin receptors and the membrane lipid fluidity may take part in the overt decrease in iron uptake by erythroid cells along the erythropoiesis pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 233-240 |
| Number of pages | 8 |
| Journal | Cell Biophysics |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sept 1980 |
| Externally published | Yes |
Keywords
- Cell density, in Friend erythroleukemic cells
- Friend erythroleukemic cells
- erythroleukemia cells, Friend
- leukemia cells, Friend
- membrane fluidity, in Friend erythroleukemic cells
- receptors, in Friend erythroleukemic cells
- transferrin receptors, in Friend erythroleukemic cells