@article{1417b0bdf90b4cbdb483ef27d984ce11,
title = "Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity",
abstract = "Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture to viral replication is insufficiently understood. Single-cell transcriptomics applying vesicular stomatitis virus infection suggests involvement of factors determining IMM architecture following infection. Consistently, inhibition of the F1FO adenosine triphosphate (ATP) synthase reduces viral replication, which is associated with oligomerization of this complex and altered IMM structure. Moreover, deletion of mitochondrial contact site and cristae organizing system (MICOS) complex by targeting MIC60 results in reduced viral replication. Generation of Mic60inv/inv CD11c-Cre+ mice uncovers reduced crista junctions and viral replication in bone marrow-derived dendritic cells. Consequently, reduced viral replication in CD11c-expressing cells limits prolonged immune activation. Altogether, by linking the F1FO ATP synthase and the MICOS complex to viral replication and immune activation, we describe links between the mitochondrial structure-metabolism and the immune response against viral infection.",
keywords = "BMDC, CP: Cell biology, CP: Microbiology, immunometabolism, innate immunity, inner mitochondrial membrane, itaconate, MIC60, MICOS, mitochondria, viral infection",
author = "Ichiro Katahira and Nina Liebrand and Michal Gorzkiewicz and Klahm, \{Niklas Paul\} and D{\v z}iuljeta Abromavi{\v c}iūtė and Julia Werner and Krings, \{Karina Stephanie\} and Sarah Orywol and Tobias Lautwein and Karl K{\"o}hrer and Diran Herebian and Ertan Mayatepek and Max Anst{\"o}tz and Bergmann, \{Ann Kathrin\} and Kondadi, \{Arun Kumar\} and Xu, \{Haifeng C.\} and Pandyra, \{Aleksandra A.\} and Takumi Kobayashi and Dirk Brenner and Thomas Floss and Ulrich Kalinke and Reichert, \{Andreas S.\} and Lang, \{Philipp A.\}",
note = "Funding: This study was supported by the German Research Foundation (DFG, RTG1949, LA2558/8-1, RE1575/4-1, RE1575/2-1, and XU160/3-1), the Jurgen Manchot Foundation (Molecules of Infection), the Volkswagen Foundation (9B797), the Christiane and Claudia Hempel Foundation, and the Medical Faculty of the Heinrich Heine University (Forschungskommission). Further support came from the German Research Foundation (DFG) under Germany{\textquoteright}s Excellence Strategy - EXC 2155 - project number 390874280. D.B. has been funded by Luxembourg National Research Fund (FNR)-CORE grant (C21/BM/15796788) and the Fondation Luxembourg (Treg HTS). A.A.P. acknowledges support from the Deutsche Jose´ Carreras Leuka¨ mie-Stiftung (DJCLS 18R/2021), the German Childhood Cancer Foundation (A2023/31), the German Federal Office for Radiation Protection (BfS), the DZIF (TTU07–711), the German Ministry for Education and Research (Bundesministerium f{\"u}r Bildung und Forschung BMBF, grant no. 01KD2410A (EDI-4-ALL), the Medical Faculty of the Heinrich Heine University (Forschungskommission), and the D{\"u}sseldorf School of Oncology. Publisher Copyright: {\textcopyright} 2025 The Authors",
year = "2025",
month = jul,
day = "22",
doi = "10.1016/j.celrep.2025.115922",
language = "English",
volume = "44",
journal = "Cell Reports",
issn = "2639-1856",
publisher = "Cell Press",
number = "7",
}