TY - JOUR
T1 - Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort
AU - Binck, Sylvia
AU - Pauly, Claire
AU - Vaillant, Michel
AU - Hipp, Geraldine
AU - Gantenbein, Manon
AU - Krueger, Rejko
AU - Diederich, Nico J.
N1 - Funding Information:
Funding. ND has received research support by the Fonds National de Recherche (FNR/06/04/05), the Fondation Think, Rotary Luxembourg and Rotary International and personal or traveling fees from Alformec (Luxembourg), Bio Expert Nieder-Olm and Klinikum Koblenz (both Germany). RK has received research grants from Fonds National de Recherche de Luxembourg (FNR) as Coordinator of the National Centre for Excellence in Research on Parkinson's disease (NCER-PD) and within the PEARL Excellence Programme [FNR/P13/6682797/Kr?ger], and the following projects MiRisk [C17/BM/11676395], MotaSYN [12719684], MAMaSyn. Work of RK was supported by the German Research Council (DFG; KR2119/8-1), the Michael J. Fox Foundation, the European Union's Horizon 2020 research and innovation program (WIDESPREAD; CENTRE-PD; grant agreement no. 692320).
Funding Information:
ND has received research support by the Fonds National de Recherche (FNR/06/04/05), the Fondation Think, Rotary Luxembourg and Rotary International and personal or traveling fees from Alformec (Luxembourg), Bio Expert Nieder-Olm and Klinikum Koblenz (both Germany). RK has received research grants from Fonds National de Recherche de Luxembourg (FNR) as Coordinator of the National Centre for Excellence in Research on Parkinson’s disease (NCER-PD) and within the PEARL Excellence Programme [FNR/P13/6682797/Krüger], and the following projects MiRisk [C17/BM/11676395], MotaSYN [12719684], MAMaSyn. Work of RK was supported by the German Research Council (DFG; KR2119/8-1), the Michael J. Fox Foundation, the European Union’s Horizon 2020 research and innovation program (WIDESPREAD; CENTRE-PD; grant agreement no. 692320).
Publisher Copyright:
© Copyright © 2020 Binck, Pauly, Vaillant, Hipp, Gantenbein, Krueger and Diederich.
PY - 2020/11/12
Y1 - 2020/11/12
N2 - Background: To establish the frequency of impulse control disorder (ICD) in Parkinson's disease (PD). Methods: Within the Luxembourg Parkinson's Study, PD patients were evaluated for ICD presence (score ≥ 1 on MDS-UPDRS I item 1.6), use of dopamine agonists (DA) and other medications. Results: 470 patients were enrolled. Among 217 patients without DA use, 6.9% scored positive for ICD, vs. 15.4% among 253 patients with DA use (p = 0.005). The regression analysis showed that age at PD diagnosis had only a minor impact on ICD occurrence, while there was no influence by gender or co-medications. The longitudinal study over 2 years in 156 patients demonstrated increasing ICD frequency in DA users (p = 0.005). Conclusion: This large and non-interventional study confirms that PD patients with DA treatment show higher frequency of ICD than patients without DA use. It newly demonstrates that ICD can develop independently from age, gender, or co-medications.
AB - Background: To establish the frequency of impulse control disorder (ICD) in Parkinson's disease (PD). Methods: Within the Luxembourg Parkinson's Study, PD patients were evaluated for ICD presence (score ≥ 1 on MDS-UPDRS I item 1.6), use of dopamine agonists (DA) and other medications. Results: 470 patients were enrolled. Among 217 patients without DA use, 6.9% scored positive for ICD, vs. 15.4% among 253 patients with DA use (p = 0.005). The regression analysis showed that age at PD diagnosis had only a minor impact on ICD occurrence, while there was no influence by gender or co-medications. The longitudinal study over 2 years in 156 patients demonstrated increasing ICD frequency in DA users (p = 0.005). Conclusion: This large and non-interventional study confirms that PD patients with DA treatment show higher frequency of ICD than patients without DA use. It newly demonstrates that ICD can develop independently from age, gender, or co-medications.
KW - Parkinson's disease (PD)
KW - dopamine agonists
KW - impulse control disorder
KW - longitudinal analysis
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85096787486&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/33281714
U2 - 10.3389/fneur.2020.578924
DO - 10.3389/fneur.2020.578924
M3 - Article
C2 - 33281714
AN - SCOPUS:85096787486
SN - 1664-2295
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 578924
ER -