@inproceedings{5c28429c0f6f44aa928bc68fd16725df,
title = "Continuous lactate monitoring by microsensors in spheroid 3D tumor cell cultures",
abstract = "This paper reports the combination of an electrochemical metabolic monitoring system with a spheroid 3D tumor cell culture environment. Precise lactate production from single human hepatocyte spheroids was continuously monitored online over hours by electrochemical microsensors, also in combination with drug exposure. The approach enhances and simplifies the determination of metabolic rates from organotypic 3D cell cultures in drug discovery and toxicology.",
keywords = "3D cell culture, lactate, microsensors, monitoring, spheroids, toxicology",
author = "A. Weltin and S. Hammer and Y. Kaminski and S. Klein and F. Noor and J. Kieninger and Urban, {G. A.}",
note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 ; Conference date: 21-06-2015 Through 25-06-2015",
year = "2015",
month = aug,
day = "5",
doi = "10.1109/TRANSDUCERS.2015.7181270",
language = "English",
series = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1695--1698",
booktitle = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",
address = "United States",
}