Consequences of the crosstalk between monocytes/macrophages and natural killer cells

Tatiana Michel*, François Hentges, Jacques Zimmer

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    103 Citations (Scopus)

    Abstract

    The interaction between natural killer (NK) cells and different other immune cells like T cells and dendritic cells is well-described, but the crosstalk with monocytes or macrophages and the nature of ligands/receptors implicated are just emerging. The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites). The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections. The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact. We will discuss the progress in matters of modulation of NK cell functions by monocytes and macrophages, in the steady state and during diseases.

    Original languageEnglish
    Article numberArticle 403
    JournalFrontiers in Immunology
    Volume3
    Issue numberJAN
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Activation
    • Cytokines
    • Infection
    • Macrophages
    • Monocytes
    • NK cells
    • Receptors

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