Concepts of activated T cell death

Dirk Brenner, Peter H. Krammer, Rüdiger Arnold*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

99 Citations (Scopus)

Abstract

Lymphocytes of the adaptive immune system play a crucial role in defending the organism against pathogens. Initial stimulation via antigen receptors induces activation and proliferation of lymphocytes to generate effector cells that clear the pathogen from the body. During the shut-down of the immune response activated lymphocytes are removed by two mechanisms. T cells that are restimulated during the end of the immune response die by activation-induced cell death (AICD), whereas activated lymphocytes which are not restimulated die by activated cell autonomous death (ACAD). Here, we discuss the regulation of AICD and ACAD in T cells and review the role of cytokines, T cell receptor (TCR) proximal signaling mediators like hematopoietic progenitor kinase 1 (HPK1) and the NF-κB pathway. We distinguish between AICD dependent on or independent of death receptor ligation, and discuss caspase-independent death of T cells.

Original languageEnglish
Pages (from-to)52-64
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Volume66
Issue number1
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Keywords

  • ACAD
  • AICD
  • Apoptosis
  • HPK1
  • Immune response
  • NF-κB
  • T cells

Fingerprint

Dive into the research topics of 'Concepts of activated T cell death'. Together they form a unique fingerprint.

Cite this