TY - JOUR
T1 - Concepts and terms for dose/volume parameters in carbon-ion radiotherapy
T2 - Conclusions of the ULICE taskforce
AU - Vogin, G.
AU - Wambersie, A.
AU - Pötter, R.
AU - Beuve, M.
AU - Combs, S. E.
AU - Magrin, G.
AU - Mayer, R.
AU - Mock, U.
AU - Sarrut, D.
AU - Schreiner, T.
AU - Fossati, P.
AU - Balosso, J.
N1 - Publisher Copyright:
© 2018 Société française de radiothérapie oncologique (SFRO)
PY - 2018/12
Y1 - 2018/12
N2 - Purpose: The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated to high linear energy transfer particles. Methods and Materials: The ULICE-WP2 taskforce included radiation oncologists involved in carbon-ion radiation therapy and International Commission on Radiation Units and Measurements, radiation biologists, expert physicists in the fields of carbon-ion radiation therapy, microdosimetry, biological modeling and image-guided radiotherapy. Consensual reports emerged from multiple discussions within both the restricted group and the wider ULICE community. Public deliverables were produced and disseminated to the European Commission. Results: Here we highlight the disparity in practices between treating centers, then address the main topics to finally elaborate specific recommendations. Although it appears relatively simple to add geometrical margins around the clinical target volume to obtain the planning target volume as performed in photon radiotherapy, this procedure is not appropriate for carbon-ion radiation therapy. Due to the variation of the radiation quality in depth, there is no generic relative biological effectiveness value for carbon-ions outside of an isolated point, for a given fractionation and specific experimental conditions. Absorbed dose and “equieffective dose” for specified conditions must always be reported. Conclusions: This work contributed to the development of standard operating procedures for carbon-ion radiation therapy clinical trials. These procedures are now being applied, particularly in the first phase III international, multicenter trial (PHRC Étoile).
AB - Purpose: The Union of Light Ion Centers in Europe (ULICE) program addressed the need for uniting scientific results for carbon-ion radiation therapy obtained by several institutions worldwide in different fields of excellence, and translating them into a real benefit to the community. Particularly, the concepts for dose/volume parameters developed in photon radiotherapy cannot be extrapolated to high linear energy transfer particles. Methods and Materials: The ULICE-WP2 taskforce included radiation oncologists involved in carbon-ion radiation therapy and International Commission on Radiation Units and Measurements, radiation biologists, expert physicists in the fields of carbon-ion radiation therapy, microdosimetry, biological modeling and image-guided radiotherapy. Consensual reports emerged from multiple discussions within both the restricted group and the wider ULICE community. Public deliverables were produced and disseminated to the European Commission. Results: Here we highlight the disparity in practices between treating centers, then address the main topics to finally elaborate specific recommendations. Although it appears relatively simple to add geometrical margins around the clinical target volume to obtain the planning target volume as performed in photon radiotherapy, this procedure is not appropriate for carbon-ion radiation therapy. Due to the variation of the radiation quality in depth, there is no generic relative biological effectiveness value for carbon-ions outside of an isolated point, for a given fractionation and specific experimental conditions. Absorbed dose and “equieffective dose” for specified conditions must always be reported. Conclusions: This work contributed to the development of standard operating procedures for carbon-ion radiation therapy clinical trials. These procedures are now being applied, particularly in the first phase III international, multicenter trial (PHRC Étoile).
KW - Carbon-ion radiotherapy
KW - Clinical trials
KW - Equieffective dose
KW - PTV
KW - Prescription
KW - Recording
KW - Specification
UR - http://www.scopus.com/inward/record.url?scp=85054640801&partnerID=8YFLogxK
U2 - 10.1016/j.canrad.2017.11.016
DO - 10.1016/j.canrad.2017.11.016
M3 - Short survey
C2 - 30327228
AN - SCOPUS:85054640801
SN - 1278-3218
VL - 22
SP - 802
EP - 809
JO - Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
JF - Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
IS - 8
ER -