Complexity of dopamine metabolism

Johannes Meiser, Daniel Weindl, Karsten Hiller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

361 Citations (Scopus)

Abstract

Parkinson's disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenous neurotoxins whereas some DA derivatives show antioxidative effects. Therefore, DA metabolism is of special importance for neuronal redox-homeostasis and viability.In this review we highlight different aspects of dopamine metabolism in the context of PD and neurodegeneration. Since most reviews focus only on single aspects of the DA system, we will give a broader overview by looking at DA biosynthesis, sequestration, degradation and oxidation chemistry at the metabolic level, as well as at the transcriptional, translational and posttranslational regulation of all enzymes involved. This is followed by a short overview of cellular models currently used in PD research. Finally, we will address the topic from a medical point of view which directly aims to encounter PD.

Original languageEnglish
Article number34
JournalCell Communication and Signaling
Volume11
Issue number1
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Aromatic L-amino acid decarboxylase
  • Catecholamines
  • Dopamine
  • Metabolism
  • Metabolomics
  • Oxidative stress
  • Parkinson's disease
  • Tetrahydrobiopterine
  • Tyrosine hydroxylase

Fingerprint

Dive into the research topics of 'Complexity of dopamine metabolism'. Together they form a unique fingerprint.

Cite this