TY - JOUR
T1 - Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort
AU - Lu, Yunxia
AU - Cross, Amanda J.
AU - Murphy, Neil
AU - Freisling, Heinz
AU - Travis, Ruth C.
AU - Ferrari, Pietro
AU - Katzke, Verena A.
AU - Kaaks, Rudolf
AU - Olsson, Åsa
AU - Johansson, Ingegerd
AU - Renström, Frida
AU - Panico, Salvatore
AU - Pala, Valeria
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Peeters, Petra H.
AU - Siersema, Peter D.
AU - Bueno-de-Mesquita, H. B.
AU - Trichopoulou, Antonia
AU - Klinaki, Eleni
AU - Tsironis, Christos
AU - Agudo, Antonio
AU - Navarro, Carmen
AU - Sánchez, María José
AU - Barricarte, Aurelio
AU - Boutron-Ruault, Marie Christine
AU - Fagherazzi, Guy
AU - Racine, Antoine
AU - Weiderpass, Elisabete
AU - Gunter, Marc J.
AU - Riboli, Elio
N1 - Publisher Copyright:
© 2016, The Author(s).
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. Methods: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. Results: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. Conclusion: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. Impact: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.
AB - Background: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. Methods: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. Results: During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. Conclusion: WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. Impact: Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.
KW - Abdominal obesity
KW - Cancer
KW - Obesity
KW - Small intestine
UR - http://www.scopus.com/inward/record.url?scp=84974792538&partnerID=8YFLogxK
U2 - 10.1007/s10552-016-0772-z
DO - 10.1007/s10552-016-0772-z
M3 - Article
C2 - 27294726
AN - SCOPUS:84974792538
SN - 0957-5243
VL - 27
SP - 919
EP - 927
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 7
ER -