TY - JOUR
T1 - Coffee drinking and mortality in 10 European countries
T2 - A multinational cohort study
AU - Gunter, Marc J.
AU - Murphy, Neil
AU - Cross, Amanda J.
AU - Dossus, Laure
AU - Dartois, Laureen
AU - Fagherazzi, Guy
AU - Kaaks, Rudolf
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Larsen, Sofus Christian
AU - Cornejo, Maria Luisa Redondo
AU - Agudo, Antonio
AU - Pérez, María José Sánchez
AU - Altzibar, Jone M.
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Khaw, Kay Tee
AU - Butterworth, Adam
AU - Bradbury, Kathryn E.
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Grioni, Sara
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Bueno-De-Mesquita, Bas
AU - Siersema, Peter
AU - Leenders, Max
AU - Beulens, Joline W.J.
AU - Uiterwaal, Cuno U.
AU - Wallström, Peter
AU - Nilsson, Lena Maria
AU - Landberg, Rikard
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Braaten, Tonje
AU - Brennan, Paul
AU - Licaj, Idlir
AU - Muller, David C.
AU - Sinha, Rashmi
AU - Wareham, Nick
AU - Riboli, Elio
N1 - Publisher Copyright:
© 2017 American College of Physicians.
PY - 2017/8/15
Y1 - 2017/8/15
N2 - Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; 7-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
AB - Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; 7-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.
UR - http://www.scopus.com/inward/record.url?scp=85027464967&partnerID=8YFLogxK
U2 - 10.7326/M16-2945
DO - 10.7326/M16-2945
M3 - Article
C2 - 28693038
AN - SCOPUS:85027464967
SN - 0003-4819
VL - 167
SP - 236
EP - 247
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 4
ER -