Clinical research tools in pediatric oncology: challenges and opportunities

Teresa de Rojas*, Anouk Neven, Alexander J. Towbin, Fernando Carceller, Francisco Bautista, David Riedl, Samantha Sodergren, Anne Sophie Darlington, Ana Fernandez-Teijeiro, Lucas Moreno

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.

Original languageEnglish
Pages (from-to)149-160
Number of pages12
JournalCancer and Metastasis Reviews
Volume39
Issue number1
DOIs
Publication statusPublished - 1 Mar 2020
Externally publishedYes

Keywords

  • AYA oncology
  • Childhood cancer
  • CTCAE
  • Quality assurance
  • Quality of life
  • RECIST

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