TY - JOUR
T1 - Clinical research tools in pediatric oncology
T2 - challenges and opportunities
AU - de Rojas, Teresa
AU - Neven, Anouk
AU - Towbin, Alexander J.
AU - Carceller, Fernando
AU - Bautista, Francisco
AU - Riedl, David
AU - Sodergren, Samantha
AU - Darlington, Anne Sophie
AU - Fernandez-Teijeiro, Ana
AU - Moreno, Lucas
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.
AB - Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.
KW - AYA oncology
KW - CTCAE
KW - Childhood cancer
KW - Quality assurance
KW - Quality of life
KW - RECIST
UR - http://www.scopus.com/inward/record.url?scp=85078004930&partnerID=8YFLogxK
U2 - 10.1007/s10555-020-09856-z
DO - 10.1007/s10555-020-09856-z
M3 - Review article
C2 - 31939050
AN - SCOPUS:85078004930
SN - 0167-7659
VL - 39
SP - 149
EP - 160
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 1
ER -