Clinical cross-over trials in phase I

Stephen Senn; Farkad Ezzet

doi:10.1177/096228029900800306

Clinical cross-over trials in phase I

Stephen Senn^*
, Farkad Ezzet

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

We review the role of cross-over trials in pharmacokinetic and pharmacodynamic studies, in particular as applied in phase I. Design and analysis considerations are covered. We also consider the use of pharmacokinetic and pharmacodynamic theories in planning cross-over trials. Finally some practical considerations are covered.

Original language	English
Pages (from-to)	263-278
Number of pages	16
Journal	Statistical Methods in Medical Research
Volume	8
Issue number	3
DOIs	https://doi.org/10.1177/096228029900800306
Publication status	Published - 1999
Externally published	Yes

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title = "Clinical cross-over trials in phase I",

abstract = "We review the role of cross-over trials in pharmacokinetic and pharmacodynamic studies, in particular as applied in phase I. Design and analysis considerations are covered. We also consider the use of pharmacokinetic and pharmacodynamic theories in planning cross-over trials. Finally some practical considerations are covered.",

author = "Stephen Senn and Farkad Ezzet",

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M3 - Review article

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JO - Statistical Methods in Medical Research

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Clinical cross-over trials in phase I

Abstract

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