Abstract
We review the role of cross-over trials in pharmacokinetic and pharmacodynamic studies, in particular as applied in phase I. Design and analysis considerations are covered. We also consider the use of pharmacokinetic and pharmacodynamic theories in planning cross-over trials. Finally some practical considerations are covered.
| Original language | English |
|---|---|
| Pages (from-to) | 263-278 |
| Number of pages | 16 |
| Journal | Statistical Methods in Medical Research |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |