Clinical cross-over trials in phase I

Stephen Senn*, Farkad Ezzet

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

We review the role of cross-over trials in pharmacokinetic and pharmacodynamic studies, in particular as applied in phase I. Design and analysis considerations are covered. We also consider the use of pharmacokinetic and pharmacodynamic theories in planning cross-over trials. Finally some practical considerations are covered.

Original languageEnglish
Pages (from-to)263-278
Number of pages16
JournalStatistical Methods in Medical Research
Volume8
Issue number3
DOIs
Publication statusPublished - 1999
Externally publishedYes

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