TY - JOUR
T1 - Circulating Selenium Concentration Is Inversely Associated With the Prevalence of Stroke
T2 - Results From the Canadian Health Measures Survey and the National Health and Nutrition Examination Survey
AU - Hu, Xue Feng
AU - Stranges, Saverio
AU - Chan, Laurie H.M.
N1 - Publisher Copyright:
© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2019/5/21
Y1 - 2019/5/21
N2 - Background: Observational studies have suggested that selenium (Se) may have beneficial effects against certain cardiovascular outcomes, with a possible U-shaped association. We assessed the hypothesis that blood Se concentration might be inversely associated with the prevalence of stroke and the relationship would be nonlinear. Methods and Results: Data collected from adult participants (aged ≥20 years) in the Canadian Health Measures Survey (CHMS 2007–2011, n=7065) and the US National Health and Nutrition Examination Survey (NHANES 2011–2012, n=5030) were analyzed. A total of 82 (1.16%) and 202 (4.02%) stroke cases were identified in CHMS and NHANES. Respondents with stroke had lower Se levels than those without stroke, with a mean difference of 16 μg/L and 12 μg/L for CHMS and NHANES, respectively. Respondents with high blood Se concentration (tertile 3) had a lower prevalence of stroke compared with those with low Se concentration (tertile 1). The adjusted odds ratios were 0.38 (95% CI: 0.15, 0.92) and 0.57 (95% CI: 0.31, 1.03) for CHMS and NHANES, respectively. A continuous decreasing trend of stroke with whole blood selenium was observed in CHMS, whereas the curve plateaued starting at 190 μg/L for NHANES, based on the cubic restricted spline regression. Sensitivity analysis using the serum and urinary Se concentrations demonstrates that our results were consistent across different selenium biomarkers. Conclusions: We observed inverse cross-sectional associations between whole blood Se and the prevalence of stroke in representative samples of the Canadian and the US population.
AB - Background: Observational studies have suggested that selenium (Se) may have beneficial effects against certain cardiovascular outcomes, with a possible U-shaped association. We assessed the hypothesis that blood Se concentration might be inversely associated with the prevalence of stroke and the relationship would be nonlinear. Methods and Results: Data collected from adult participants (aged ≥20 years) in the Canadian Health Measures Survey (CHMS 2007–2011, n=7065) and the US National Health and Nutrition Examination Survey (NHANES 2011–2012, n=5030) were analyzed. A total of 82 (1.16%) and 202 (4.02%) stroke cases were identified in CHMS and NHANES. Respondents with stroke had lower Se levels than those without stroke, with a mean difference of 16 μg/L and 12 μg/L for CHMS and NHANES, respectively. Respondents with high blood Se concentration (tertile 3) had a lower prevalence of stroke compared with those with low Se concentration (tertile 1). The adjusted odds ratios were 0.38 (95% CI: 0.15, 0.92) and 0.57 (95% CI: 0.31, 1.03) for CHMS and NHANES, respectively. A continuous decreasing trend of stroke with whole blood selenium was observed in CHMS, whereas the curve plateaued starting at 190 μg/L for NHANES, based on the cubic restricted spline regression. Sensitivity analysis using the serum and urinary Se concentrations demonstrates that our results were consistent across different selenium biomarkers. Conclusions: We observed inverse cross-sectional associations between whole blood Se and the prevalence of stroke in representative samples of the Canadian and the US population.
KW - Canadian Health Measures Survey
KW - National Health and Nutrition Examination Survey
KW - diet
KW - environment
KW - selenium
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85066821675&partnerID=8YFLogxK
U2 - 10.1161/JAHA.119.012290
DO - 10.1161/JAHA.119.012290
M3 - Article
C2 - 31084244
AN - SCOPUS:85066821675
SN - 2047-9980
VL - 8
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 10
M1 - e012290
ER -