TY - JOUR
T1 - Circulating microRNAs to predict heart failure after acute myocardial infarction in women
AU - Lalem, Torkia
AU - Devaux, Yvan
N1 - Funding Information:
The authors are members of the Cardiolinc™ network (www.cardiolinc.org). This work was supported by the Ministry of Higher Education and Research and the Society for Research on Cardiovascular Diseases of Luxembourg. None.
Funding Information:
This work was supported by the Ministry of Higher Education and Research and the Society for Research on Cardiovascular Diseases of Luxembourg .
Publisher Copyright:
© 2019 The Canadian Society of Clinical Chemists
PY - 2019/8
Y1 - 2019/8
N2 - Left ventricular remodeling after acute myocardial infarction affects cardiac function and increases the risk of developing heart failure. Despite the emergence of biomarkers associated with remodeling, the ideal biomarker to accurately predict the risk of developing heart failure after acute myocardial infarction is still to be discovered. Female and male hearts cope differently with ischemic stress, leading to different consequences on cardiac morphology and function. As biomarkers reflect the pathogenesis of remodeling, utilization of sex-specific biomarkers might improve risk stratification. Expressed in cardiac and inflammatory cells, microRNAs regulate several biological pathways triggering the remodeling process. In addition, circulating microRNAs are associated with the risk of developing heart failure after acute myocardial infarction, hence their biomarker potential. Interestingly, multiple microRNAs display sex-specific expression profiles as they can be modulated by sexual hormones and escape X-inactivation, for those located on the X-chromosome. This review article aims to discuss the potential of circulating microRNAs to predict heart failure after acute myocardial infarction in a sex-specific manner.
AB - Left ventricular remodeling after acute myocardial infarction affects cardiac function and increases the risk of developing heart failure. Despite the emergence of biomarkers associated with remodeling, the ideal biomarker to accurately predict the risk of developing heart failure after acute myocardial infarction is still to be discovered. Female and male hearts cope differently with ischemic stress, leading to different consequences on cardiac morphology and function. As biomarkers reflect the pathogenesis of remodeling, utilization of sex-specific biomarkers might improve risk stratification. Expressed in cardiac and inflammatory cells, microRNAs regulate several biological pathways triggering the remodeling process. In addition, circulating microRNAs are associated with the risk of developing heart failure after acute myocardial infarction, hence their biomarker potential. Interestingly, multiple microRNAs display sex-specific expression profiles as they can be modulated by sexual hormones and escape X-inactivation, for those located on the X-chromosome. This review article aims to discuss the potential of circulating microRNAs to predict heart failure after acute myocardial infarction in a sex-specific manner.
KW - Acute myocardial infarction
KW - Biomarker
KW - Heart failure
KW - Left ventricular remodeling
KW - Sex
KW - microRNA
UR - http://www.scopus.com/inward/record.url?scp=85066156541&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2019.05.011
DO - 10.1016/j.clinbiochem.2019.05.011
M3 - Review article
C2 - 31132347
AN - SCOPUS:85066156541
SN - 0009-9120
VL - 70
SP - 1
EP - 7
JO - Clinical Biochemistry
JF - Clinical Biochemistry
ER -