@article{1dc389d4f416438b86e936d88e482c28,
title = "Circulating levels of microRNA 423-5p are associated with 90 day mortality in cardiogenic shock",
abstract = "Aims: The role of microRNAs has not been studied in cardiogenic shock. We examined the potential role of miR-423-5p level to predict mortality and associations of miR-423-5p with prognostic markers in cardiogenic shock. Methods and results: We conducted a prospective multinational observational study enrolling consecutive cardiogenic shock patients. Blood samples were available for 179 patients at baseline to determine levels of miR-423-5p and other biomarkers. Patients were treated according to local practice. Main outcome was 90 day all-cause mortality. Median miR-423-5p level was significantly higher in 90 day non-survivors [median 0.008 arbitrary units (AU) (interquartile range 0.003–0.017) vs. 0.004 AU (0.002–0.009), P = 0.003]. miR-423-5p level above median was associated with higher lactate (median 3.7 vs. 2.4 mmol/L, P = 0.001) and alanine aminotransferase levels (median 68 vs. 35 IU/L, P < 0.001) as well as lower cardiac index (1.8 vs. 2.4, P = 0.04) and estimated glomerular filtration rate (56 vs. 70 mL/min/1.73 m2, P = 0.002). In Cox regression analysis, miR-423-5p level above median was associated with 90 day all-cause mortality independently of established risk factors of cardiogenic shock [adjusted hazard ratio 1.9 (95% confidence interval 1.2–3.2), P = 0.01]. Conclusions: In cardiogenic shock patients, above median level of miR-423-5p at baseline is associated with markers of hypoperfusion and seems to independently predict 90 day all-cause mortality.",
keywords = "Acute coronary syndrome, Cardiogenic shock, Mortality, Prognosis, miR-423-5p, microRNA",
author = "Toni J{\"a}ntti and Heli Segersv{\"a}rd and Heli Tolppanen and Tuukka Tarvasm{\"a}ki and Johan Lassus and Yvan Devaux and M{\'e}lanie Vausort and Kari Pulkki and Alessandro Sionis and Antoni Bayes-Genis and Ilkka Tikkanen and P{\"a}ivi Lakkisto and Harjola, {Veli Pekka}",
note = "Funding Information: This work was supported by grants from the Finnish Foundation for Cardiovascular Research, Aarne Koskelo Foundation, Finnish Foundation for Laboratory Medicine, Finska L{\"a}kares{\"a}llskapet, the Liv och H{\"a}lsa Foundation, and Finnish state funding for university-level research. Roche Diagnostics provided kits for the analysis of hsTnT. The funding sources had no role in the design and conduct of the study; collection, Funding Information: This work was supported by grants from the Finnish Foundation for Cardiovascular Research, Aarne Koskelo Foundation, Finnish Foundation for Laboratory Medicine, Finska L?kares?llskapet, the Liv och H?lsa Foundation, and Finnish state funding for university-level research. Roche Diagnostics provided kits for the analysis of hsTnT. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The authors wish to acknowledge the expert technical assistance of Ms. Katariina Immonen, MSc. The CardShock steering committee: Veli-Pekka Harjola (chair), Marek Banaszewski, Lars K?ber, Johan Lassus, Alexandre Mebazaa, Marco Metra, John Parissis, Jose Silva-Cardoso, Alessandro Sionis, Salvatore Di Somma, and Jindrich Spinar. List of investigators: in Athens are Katerina Koniari, Astrinos Voumvourakis, and Apostolos Karavidas; in Barcelona are Jordi Sans-Rosello, Montserrat Vila, and Albert Duran-Cambra; in Brescia are Marco Metra, Michela Bulgari, and Valentina Lazzarini; in Brno are Jiri Parenica, Roman Stipal, Ondrej Ludka, Marie Palsuva, Eva Ganovska, and Petr Kubena; in Copenhagen are Matias G. Lindholm and Christian Hassager; in Helsinki are Tom B?cklund, Raija Jurkko, Kristiina J?rvinen, Tuomo Nieminen, Kari Pulkki, Leena Soininen, Reijo Sund, Ilkka Tierala, Jukka Tolonen, Marjut Varpula, Tuomas Korva, and Anne Pitk?l?; in Rome is Rossella Marino; in Porto are Alexandra Sousa, Carla Sousa, Mariana Paiva, In?s Rangel, Rui Almeida, Teresa Pinho, and Maria J?lia Maciel; and in Warsaw are Janina Stepinska, Anna Skrobisz, and Piotr G?ral. The study was performed in collaboration with the GREAT network. Publisher Copyright: {\textcopyright} 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.",
year = "2019",
month = feb,
doi = "10.1002/ehf2.12377",
language = "English",
volume = "6",
pages = "98--102",
journal = "ESC heart failure",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "1",
}