Circular RNAs in the cardiovascular system

Clarissa P.C. Gomes, Antonio Salgado-Somoza, Esther E. Creemers, Christoph Dieterich, Mitja Lustrek, Yvan Devaux*, Cardiolinc™ network

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalNon-coding RNA Research
Issue number1
Publication statusPublished - Mar 2018


  • Artificial intelligence
  • Biomarker
  • Cardiovascular disease
  • Cardiovascular system
  • Circular RNAs
  • Non-coding RNAs

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