Chemopreventive and therapeutic effects of curcumin

Annelyse Duvoix, Romain Blasius, Sylvie Delhalle, Michaël Schnekenburger, Franck Morceau, Estelle Henry, Mario Dicato, Marc Diederich*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

778 Citations (Scopus)

Abstract

Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalCancer Letters
Volume223
Issue number2
DOIs
Publication statusPublished - 8 Jun 2005
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Chemopreventive agent
  • Curcumin
  • Drug metabolism

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