Chemical constituents of cassia abbreviata and their anti-hiv-1 activity

Xianwen Yang; Zhihui He; Yue Zheng; Ning Wang; Martin Mulinge; Jean Claude Schmit; André Steinmetz; Carole Seguin-Devaux

doi:10.3390/molecules26092455

Chemical constituents of cassia abbreviata and their anti-hiv-1 activity

Xianwen Yang, Zhihui He, Yue Zheng, Ning Wang, Martin Mulinge, Jean Claude Schmit, André Steinmetz, Carole Seguin-Devaux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatan-nol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC₅₀ values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

Original language	English
Article number	2455
Journal	Molecules
Volume	26
Issue number	9
DOIs	https://doi.org/10.3390/molecules26092455
Publication status	Published - 23 Apr 2021

Keywords

Anti-HIV
Cassia abbreviata
Fabaceae
Flavonoid
Heterodimer

Access to Document

10.3390/molecules26092455Licence: CC BY

Cite this

@article{28f7a480c5ac4f6ca2ba37abda550b10,

title = "Chemical constituents of cassia abbreviata and their anti-hiv-1 activity",

abstract = "Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatan-nol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC50 values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.",

keywords = "Anti-HIV, Cassia abbreviata, Fabaceae, Flavonoid, Heterodimer",

author = "Xianwen Yang and Zhihui He and Yue Zheng and Ning Wang and Martin Mulinge and Schmit, {Jean Claude} and Andr{\'e} Steinmetz and Carole Seguin-Devaux",

note = "Funding Information: Funding: This work was supported by the “Fonds National de la Recherche” of Luxembourg [PHD AFR grant 1189522] and the Luxembourg Institute of Health (MESR grant 20150415). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = apr,

day = "23",

doi = "10.3390/molecules26092455",

language = "English",

volume = "26",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

TY - JOUR

T1 - Chemical constituents of cassia abbreviata and their anti-hiv-1 activity

AU - Yang, Xianwen

AU - He, Zhihui

AU - Zheng, Yue

AU - Wang, Ning

AU - Mulinge, Martin

AU - Schmit, Jean Claude

AU - Steinmetz, André

AU - Seguin-Devaux, Carole

N1 - Funding Information: Funding: This work was supported by the “Fonds National de la Recherche” of Luxembourg [PHD AFR grant 1189522] and the Luxembourg Institute of Health (MESR grant 20150415). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/4/23

Y1 - 2021/4/23

N2 - Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatan-nol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC50 values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

AB - Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatan-nol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC50 values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

KW - Anti-HIV

KW - Cassia abbreviata

KW - Fabaceae

KW - Flavonoid

KW - Heterodimer

UR - http://www.scopus.com/inward/record.url?scp=85105085222&partnerID=8YFLogxK

UR - https://www.ncbi.nlm.nih.gov/pubmed/33922460

U2 - 10.3390/molecules26092455

DO - 10.3390/molecules26092455

M3 - Article

C2 - 33922460

AN - SCOPUS:85105085222

SN - 1420-3049

VL - 26

JO - Molecules

JF - Molecules

IS - 9

M1 - 2455

ER -

Chemical constituents of cassia abbreviata and their anti-hiv-1 activity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this