Chemical constituents of cassia abbreviata and their anti-hiv-1 activity

Xianwen Yang, Zhihui He, Yue Zheng, Ning Wang, Martin Mulinge, Jean Claude Schmit, André Steinmetz, Carole Seguin-Devaux*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Three new (1–3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4α→8)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatan-nol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC50 values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

Original languageEnglish
Article number2455
Issue number9
Publication statusPublished - 23 Apr 2021


  • Anti-HIV
  • Cassia abbreviata
  • Fabaceae
  • Flavonoid
  • Heterodimer


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