Chemical constituents of Abies nukiangensis

Yong Li Li; Yan Xia Gao; Hui Zi Jin; Lei Shan; Xue Song Liang; Xi Ke Xu; Xian Wen Yang; Ning Wang; Andre Steinmetz; Zhilei Chen; Wei Dong Zhang

doi:10.1016/j.phytochem.2014.07.003

Chemical constituents of Abies nukiangensis

Yong Li Li
, Yan Xia Gao
, Hui Zi Jin
, Lei Shan
, Xue Song Liang
, Xi Ke Xu
, Xian Wen Yang^*
, Ning Wang
, Andre Steinmetz
, Zhilei Chen
, Wei Dong Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC₅₀ values of 3.73, 2.67, 1.33 and 2.25 μM, respectively.

Original language	English
Pages (from-to)	116-123
Number of pages	8
Journal	Phytochemistry
Volume	106
DOIs	https://doi.org/10.1016/j.phytochem.2014.07.003
Publication status	Published - Oct 2014

Keywords

Abies nukiangensis
Abietoideae
Cu-Kα X-ray crystallography
Hepatitis C virus (HCV)
Pinaceae
Triterpenoids

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10.1016/j.phytochem.2014.07.003

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@article{7ce75773dc474d2c8fab8a0987ab4540,

title = "Chemical constituents of Abies nukiangensis",

abstract = "During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25 μM, respectively.",

keywords = "Abies nukiangensis, Abietoideae, Cu-Kα X-ray crystallography, Hepatitis C virus (HCV), Pinaceae, Triterpenoids",

author = "Li, \{Yong Li\} and Gao, \{Yan Xia\} and Jin, \{Hui Zi\} and Lei Shan and Liang, \{Xue Song\} and Xu, \{Xi Ke\} and Yang, \{Xian Wen\} and Ning Wang and Andre Steinmetz and Zhilei Chen and Zhang, \{Wei Dong\}",

note = "Funding Information: The work was supported by program NCET Foundation, NSFC, China ( 81230090 , 21372233 , 41176148 ), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products ( 10DZ2251300 ), the Scientific Foundation of Shanghai, China ( 12401900801 , 13401900101 ), National Major Project of China ( 2011ZX09307-002-03 ) and the National Key Technology R\&D Program of China ( 2012BAI29B06 ). ",

year = "2014",

month = oct,

doi = "10.1016/j.phytochem.2014.07.003",

language = "English",

volume = "106",

pages = "116--123",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

}

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T1 - Chemical constituents of Abies nukiangensis

AU - Li, Yong Li

AU - Gao, Yan Xia

AU - Jin, Hui Zi

AU - Shan, Lei

AU - Liang, Xue Song

AU - Xu, Xi Ke

AU - Yang, Xian Wen

AU - Wang, Ning

AU - Steinmetz, Andre

AU - Chen, Zhilei

AU - Zhang, Wei Dong

N1 - Funding Information: The work was supported by program NCET Foundation, NSFC, China ( 81230090 , 21372233 , 41176148 ), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products ( 10DZ2251300 ), the Scientific Foundation of Shanghai, China ( 12401900801 , 13401900101 ), National Major Project of China ( 2011ZX09307-002-03 ) and the National Key Technology R&D Program of China ( 2012BAI29B06 ).

PY - 2014/10

Y1 - 2014/10

N2 - During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25 μM, respectively.

AB - During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25 μM, respectively.

KW - Abies nukiangensis

KW - Abietoideae

KW - Cu-Kα X-ray crystallography

KW - Hepatitis C virus (HCV)

KW - Pinaceae

KW - Triterpenoids

UR - https://www.scopus.com/pages/publications/84906943705

U2 - 10.1016/j.phytochem.2014.07.003

DO - 10.1016/j.phytochem.2014.07.003

M3 - Article

C2 - 25081106

AN - SCOPUS:84906943705

SN - 0031-9422

VL - 106

SP - 116

EP - 123

JO - Phytochemistry

JF - Phytochemistry

ER -

Chemical constituents of Abies nukiangensis

Abstract

Keywords

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