Chemical constituents of Abies nukiangensis

Yong Li Li, Yan Xia Gao, Hui Zi Jin, Lei Shan, Xue Song Liang, Xi Ke Xu, Xian Wen Yang*, Ning Wang, Andre Steinmetz, Zhilei Chen, Wei Dong Zhang

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    15 Citations (Scopus)

    Abstract

    During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25 μM, respectively.

    Original languageEnglish
    Pages (from-to)116-123
    Number of pages8
    JournalPhytochemistry
    Volume106
    DOIs
    Publication statusPublished - Oct 2014

    Keywords

    • Abies nukiangensis
    • Abietoideae
    • Cu-Kα X-ray crystallography
    • Hepatitis C virus (HCV)
    • Pinaceae
    • Triterpenoids

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