Chemical constituents of Abies fabri

Yong Li Li, Yan Xia Gao, Hui Zi Jin, Lei Shan, Wan Lin Chang, Xian Wen Yang*, Hua Wu Zeng, Ning Wang, Andre Steinmetz, Wei Dong Zhang

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 μM, respectively.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalPhytochemistry
Volume117
DOIs
Publication statusPublished - 13 Jun 2015

Keywords

  • Abies fabri
  • Cu-Kα X-ray crystallography
  • Cytotoxicity
  • Diterpenoids
  • Pinaceae
  • Triterpenoids

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