Chemical constituents of Abies fabri

Yong Li Li; Yan Xia Gao; Hui Zi Jin; Lei Shan; Wan Lin Chang; Xian Wen Yang; Hua Wu Zeng; Ning Wang; Andre Steinmetz; Wei Dong Zhang

doi:10.1016/j.phytochem.2015.06.012

Chemical constituents of Abies fabri

Yong Li Li, Yan Xia Gao, Hui Zi Jin, Lei Shan, Wan Lin Chang, Xian Wen Yang^*, Hua Wu Zeng, Ning Wang, Andre Steinmetz, Wei Dong Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)

Abstract

Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC₅₀ values of 5.3 and 5.1 μM, respectively.

Original language	English
Pages (from-to)	135-143
Number of pages	9
Journal	Phytochemistry
Volume	117
DOIs	https://doi.org/10.1016/j.phytochem.2015.06.012
Publication status	Published - 13 Jun 2015

Keywords

Abies fabri
Cu-Kα X-ray crystallography
Cytotoxicity
Diterpenoids
Pinaceae
Triterpenoids

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10.1016/j.phytochem.2015.06.012

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title = "Chemical constituents of Abies fabri",

abstract = "Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 μM, respectively.",

keywords = "Abies fabri, Cu-Kα X-ray crystallography, Cytotoxicity, Diterpenoids, Pinaceae, Triterpenoids",

author = "Li, {Yong Li} and Gao, {Yan Xia} and Jin, {Hui Zi} and Lei Shan and Chang, {Wan Lin} and Yang, {Xian Wen} and Zeng, {Hua Wu} and Ning Wang and Andre Steinmetz and Zhang, {Wei Dong}",

note = "Funding Information: The work was supported by program New Century Excellent Talents in University of China , NSFC ( 81230090 , 21372233 , 41176148 ), Shanghai Leading Academic Discipline Project (B906), Key Laboratory of Drug Research for special environments, PLA , Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products ( 10DZ2251300 ), the Scientific Foundation of Shanghai China ( 12401900801 , 13401900101 ), National Major Project of China (2011ZX09307-002-03) and the National Key Technology R&D Program of China (2012BAI29B06). Publisher Copyright: {\textcopyright} 2015, Elsevier Ltd. All rights reserved.",

year = "2015",

month = jun,

day = "13",

doi = "10.1016/j.phytochem.2015.06.012",

language = "English",

volume = "117",

pages = "135--143",

journal = "Phytochemistry",

issn = "0031-9422",

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T1 - Chemical constituents of Abies fabri

AU - Li, Yong Li

AU - Gao, Yan Xia

AU - Jin, Hui Zi

AU - Shan, Lei

AU - Chang, Wan Lin

AU - Yang, Xian Wen

AU - Zeng, Hua Wu

AU - Wang, Ning

AU - Steinmetz, Andre

AU - Zhang, Wei Dong

N1 - Funding Information: The work was supported by program New Century Excellent Talents in University of China , NSFC ( 81230090 , 21372233 , 41176148 ), Shanghai Leading Academic Discipline Project (B906), Key Laboratory of Drug Research for special environments, PLA , Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products ( 10DZ2251300 ), the Scientific Foundation of Shanghai China ( 12401900801 , 13401900101 ), National Major Project of China (2011ZX09307-002-03) and the National Key Technology R&D Program of China (2012BAI29B06). Publisher Copyright: © 2015, Elsevier Ltd. All rights reserved.

PY - 2015/6/13

Y1 - 2015/6/13

N2 - Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 μM, respectively.

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KW - Abies fabri

KW - Cu-Kα X-ray crystallography

KW - Cytotoxicity

KW - Diterpenoids

KW - Pinaceae

KW - Triterpenoids

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SN - 0031-9422

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JO - Phytochemistry

JF - Phytochemistry

ER -

Chemical constituents of Abies fabri

Abstract

Keywords

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