Chemical constituents of Abies delavayi

Xian Wen Yang, Su Mei Li, Yong Li Li, Lin Feng, Yun Heng Shen, Shen Lin, Jun Mian Tian, Hua Wu Zeng, Ning Wang, Andre Steinmetz, Yonghong Liu, Wei Dong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 ± 3.7 μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi- manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 μg/mL.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalPhytochemistry
Volume105
DOIs
Publication statusPublished - Sep 2014

Keywords

  • Abies delavayi
  • Cytotoxicity
  • Monoterpenes
  • Nitric oxide (NO)
  • Phenols
  • Pinaceae
  • Sesquiterpenes
  • Triterpenoids

Fingerprint

Dive into the research topics of 'Chemical constituents of Abies delavayi'. Together they form a unique fingerprint.

Cite this