Chemical constituents of Abies delavayi

Xian Wen Yang; Su Mei Li; Yong Li Li; Lin Feng; Yun Heng Shen; Shen Lin; Jun Mian Tian; Hua Wu Zeng; Ning Wang; Andre Steinmetz; Yonghong Liu; Wei Dong Zhang

doi:10.1016/j.phytochem.2014.05.012

Chemical constituents of Abies delavayi

Xian Wen Yang, Su Mei Li, Yong Li Li, Lin Feng, Yun Heng Shen, Shen Lin, Jun Mian Tian, Hua Wu Zeng, Ning Wang, Andre Steinmetz, Yonghong Liu, Wei Dong Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Abstract

Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC₅₀ value of 19.0 ± 3.7 μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi- manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC₅₀ values of approximately 50 μg/mL.

Original language	English
Pages (from-to)	164-170
Number of pages	7
Journal	Phytochemistry
Volume	105
DOIs	https://doi.org/10.1016/j.phytochem.2014.05.012
Publication status	Published - Sept 2014

Keywords

Abies delavayi
Cytotoxicity
Monoterpenes
Nitric oxide (NO)
Phenols
Pinaceae
Sesquiterpenes
Triterpenoids

Access to Document

10.1016/j.phytochem.2014.05.012

Cite this

@article{9045b12934b84f449e70a83b719d5134,

title = "Chemical constituents of Abies delavayi",

abstract = "Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 ± 3.7 μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi- manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 μg/mL.",

keywords = "Abies delavayi, Cytotoxicity, Monoterpenes, Nitric oxide (NO), Phenols, Pinaceae, Sesquiterpenes, Triterpenoids",

author = "Yang, {Xian Wen} and Li, {Su Mei} and Li, {Yong Li} and Lin Feng and Shen, {Yun Heng} and Shen Lin and Tian, {Jun Mian} and Zeng, {Hua Wu} and Ning Wang and Andre Steinmetz and Yonghong Liu and Zhang, {Wei Dong}",

note = "Funding Information: This work was financially supported by the NCET Foundation, NSFC (81230090, 41176148, and 21372233), Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project, 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and partially supported by the Scientific Foundation of Shanghai China (09DZ1975700, 09DZ1971500, 10DZ1971700), National Major Project of China (2011ZX09307-002-03), and National Key Technology R&D Program of China (2012BAI29B06). ",

year = "2014",

month = sep,

doi = "10.1016/j.phytochem.2014.05.012",

language = "English",

volume = "105",

pages = "164--170",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Chemical constituents of Abies delavayi

AU - Yang, Xian Wen

AU - Li, Su Mei

AU - Li, Yong Li

AU - Feng, Lin

AU - Shen, Yun Heng

AU - Lin, Shen

AU - Tian, Jun Mian

AU - Zeng, Hua Wu

AU - Wang, Ning

AU - Steinmetz, Andre

AU - Liu, Yonghong

AU - Zhang, Wei Dong

N1 - Funding Information: This work was financially supported by the NCET Foundation, NSFC (81230090, 41176148, and 21372233), Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project, 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and partially supported by the Scientific Foundation of Shanghai China (09DZ1975700, 09DZ1971500, 10DZ1971700), National Major Project of China (2011ZX09307-002-03), and National Key Technology R&D Program of China (2012BAI29B06).

PY - 2014/9

Y1 - 2014/9

N2 - Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 ± 3.7 μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi- manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 μg/mL.

AB - Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 ± 3.7 μg/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi- manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 μg/mL.

KW - Abies delavayi

KW - Cytotoxicity

KW - Monoterpenes

KW - Nitric oxide (NO)

KW - Phenols

KW - Pinaceae

KW - Sesquiterpenes

KW - Triterpenoids

UR - http://www.scopus.com/inward/record.url?scp=84905491289&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2014.05.012

DO - 10.1016/j.phytochem.2014.05.012

M3 - Article

C2 - 24916321

AN - SCOPUS:84905491289

SN - 0031-9422

VL - 105

SP - 164

EP - 170

JO - Phytochemistry

JF - Phytochemistry

ER -

Chemical constituents of Abies delavayi

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this