Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

Alessandro Michelucci, Tony Heurtaux, Luc Grandbarbe, Eleonora Morga, Paul Heuschling*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

317 Citations (Scopus)

Abstract

M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-γ induce a M1-like phenotype, while IL-10 or IL-4 differentiate microglia towards a M2-deactivated or M2-alternatively-activated phenotype respectively. These differentiation processes also affect the Notch pathway. In order to study the polarization induced by Aβ, microglia was stimulated with different forms of the peptide. The oligomeric Aβ is a stronger M1-inductor than the fibrillar form. Moreover, a cytokine-induced anti-inflammatory environment reduces the microglial reactivity towards oligomeric Aβ.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalJournal of Neuroimmunology
Volume210
Issue number1-2
DOIs
Publication statusPublished - 29 May 2009
Externally publishedYes

Keywords

  • Alternative activation
  • Microglia
  • Notch
  • Phagocytosis
  • Signature genes

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