TY - JOUR
T1 - Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses
T2 - Possible consequences for therapy and infection control
AU - Veljkovic, Veljko
AU - Veljkovic, Nevena
AU - Muller, Claude P.
AU - Müller, Sybille
AU - Glisic, Sanja
AU - Perovic, Vladimir
AU - Köhler, Heinz
N1 - Funding Information:
This work was supported by the Ministry of Science and Technological Development of the Republic of Serbia (Grant no. 143001). COST Action B28 is gratefully acknowledged.
PY - 2009
Y1 - 2009
N2 - Background. Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the world's economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. Results. Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1. Conclusion. The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
AB - Background. Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the world's economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. Results. Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1. Conclusion. The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
UR - http://www.scopus.com/inward/record.url?scp=65549155359&partnerID=8YFLogxK
U2 - 10.1186/1472-6807-9-21
DO - 10.1186/1472-6807-9-21
M3 - Article
C2 - 19351406
AN - SCOPUS:65549155359
SN - 1472-6807
VL - 9
JO - BMC Structural Biology
JF - BMC Structural Biology
M1 - 21
ER -