Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study

Shu Chun Chuang; Heiner Boeing; Stein Emil Vollset; Øivind Midttun; Per Magne Ueland; Bas Bueno-de-Mesquita; Martin Lajous; Guy Fagherazzi; Marie Christine Boutron-Ruault; Rudolf Kaaks; Tilman Küehn; Tobias Pischon; Dagmar Drogan; Anne Tjønneland; Kim Overvad; J. Ramón Quirós; Antonio Agudo; Esther Molina-Montes; Miren Dorronsoro; José María Huerta; Aurelio Barricarte; Kay Tee Khaw; Nicholas J. Wareham; Ruth C. Travis; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Amalia Mattiello; Petra H. Peeters; Elisabete Weiderpass; Richard Palmqvist; Ingrid Ljuslinder; Marc Gunter; Yunxia Lu; Amanda J. Cross; Elio Riboli; Paolo Vineis; Krasimira Aleksandrova

doi:10.1186/s12979-016-0059-y

Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study

Shu Chun Chuang^*, Heiner Boeing, Stein Emil Vollset, Øivind Midttun, Per Magne Ueland, Bas Bueno-de-Mesquita, Martin Lajous, Guy Fagherazzi, Marie Christine Boutron-Ruault, Rudolf Kaaks, Tilman Küehn, Tobias Pischon, Dagmar Drogan, Anne Tjønneland, Kim Overvad, J. Ramón Quirós, Antonio Agudo, Esther Molina-Montes, Miren Dorronsoro, José María HuertaAurelio Barricarte, Kay Tee Khaw, Nicholas J. Wareham, Ruth C. Travis, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Amalia Mattiello, Petra H. Peeters, Elisabete Weiderpass, Richard Palmqvist, Ingrid Ljuslinder, Marc Gunter, Yunxia Lu, Amanda J. Cross, Elio Riboli, Paolo Vineis, Krasimira Aleksandrova

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.

Original language	English
Article number	5
Journal	Immunity and Ageing
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s12979-016-0059-y
Publication status	Published - 25 Feb 2016
Externally published	Yes

Keywords

Cell-mediated immunity
Metabolic syndrome
Neopterin

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Chuang, S. C., Boeing, H., Vollset, S. E., Midttun, Ø., Ueland, P. M., Bueno-de-Mesquita, B., Lajous, M., Fagherazzi, G., Boutron-Ruault, M. C., Kaaks, R., Küehn, T., Pischon, T., Drogan, D., Tjønneland, A., Overvad, K., Quirós, J. R., Agudo, A., Molina-Montes, E., Dorronsoro, M., ... Aleksandrova, K. (2016). Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study. Immunity and Ageing, 13(1), Article 5. https://doi.org/10.1186/s12979-016-0059-y

@article{cc397a5319a243daadeadd87743b17c3,

title = "Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study",

abstract = "Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.",

keywords = "Cell-mediated immunity, Metabolic syndrome, Neopterin",

author = "Chuang, {Shu Chun} and Heiner Boeing and Vollset, {Stein Emil} and {\O}ivind Midttun and Ueland, {Per Magne} and Bas Bueno-de-Mesquita and Martin Lajous and Guy Fagherazzi and Boutron-Ruault, {Marie Christine} and Rudolf Kaaks and Tilman K{\"u}ehn and Tobias Pischon and Dagmar Drogan and Anne Tj{\o}nneland and Kim Overvad and Quir{\'o}s, {J. Ram{\'o}n} and Antonio Agudo and Esther Molina-Montes and Miren Dorronsoro and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Travis, {Ruth C.} and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Giovanna Masala and Claudia Agnoli and Rosario Tumino and Amalia Mattiello and Peeters, {Petra H.} and Elisabete Weiderpass and Richard Palmqvist and Ingrid Ljuslinder and Marc Gunter and Yunxia Lu and Cross, {Amanda J.} and Elio Riboli and Paolo Vineis and Krasimira Aleksandrova",

note = "Publisher Copyright: {\textcopyright} 2016 Chuang et al.",

year = "2016",

month = feb,

day = "25",

doi = "10.1186/s12979-016-0059-y",

language = "English",

volume = "13",

journal = "Immunity and Ageing",

issn = "1742-4933",

publisher = "BioMed Central Ltd.",

number = "1",

}

Chuang, SC, Boeing, H, Vollset, SE, Midttun, Ø, Ueland, PM, Bueno-de-Mesquita, B, Lajous, M, Fagherazzi, G, Boutron-Ruault, MC, Kaaks, R, Küehn, T, Pischon, T, Drogan, D, Tjønneland, A, Overvad, K, Quirós, JR, Agudo, A, Molina-Montes, E, Dorronsoro, M, Huerta, JM, Barricarte, A, Khaw, KT, Wareham, NJ, Travis, RC, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Agnoli, C, Tumino, R, Mattiello, A, Peeters, PH, Weiderpass, E, Palmqvist, R, Ljuslinder, I, Gunter, M, Lu, Y, Cross, AJ, Riboli, E, Vineis, P & Aleksandrova, K 2016, 'Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study', Immunity and Ageing, vol. 13, no. 1, 5. https://doi.org/10.1186/s12979-016-0059-y

TY - JOUR

T1 - Cellular immune activity biomarker neopterin is associated hyperlipidemia

T2 - Results from a large population-based study

AU - Chuang, Shu Chun

AU - Boeing, Heiner

AU - Vollset, Stein Emil

AU - Midttun, Øivind

AU - Ueland, Per Magne

AU - Bueno-de-Mesquita, Bas

AU - Lajous, Martin

AU - Fagherazzi, Guy

AU - Boutron-Ruault, Marie Christine

AU - Kaaks, Rudolf

AU - Küehn, Tilman

AU - Pischon, Tobias

AU - Drogan, Dagmar

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Quirós, J. Ramón

AU - Agudo, Antonio

AU - Molina-Montes, Esther

AU - Dorronsoro, Miren

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Mattiello, Amalia

AU - Peeters, Petra H.

AU - Weiderpass, Elisabete

AU - Palmqvist, Richard

AU - Ljuslinder, Ingrid

AU - Gunter, Marc

AU - Lu, Yunxia

AU - Cross, Amanda J.

AU - Riboli, Elio

AU - Vineis, Paolo

AU - Aleksandrova, Krasimira

PY - 2016/2/25

Y1 - 2016/2/25

N2 - Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.

AB - Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.

KW - Cell-mediated immunity

KW - Metabolic syndrome

KW - Neopterin

UR - http://www.scopus.com/inward/record.url?scp=84975682924&partnerID=8YFLogxK

U2 - 10.1186/s12979-016-0059-y

DO - 10.1186/s12979-016-0059-y

M3 - Article

AN - SCOPUS:84975682924

SN - 1742-4933

VL - 13

JO - Immunity and Ageing

JF - Immunity and Ageing

IS - 1

M1 - 5

ER -

Cellular immune activity biomarker neopterin is associated hyperlipidemia: Results from a large population-based study

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Keywords

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