CD56bright natural killer (NK) cells: An important NK cell subset

Aurélie Poli, Tatiana Michel, Maud Thérésine, Emmanuel Andrès, François Hentges, Jacques Zimmer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

660 Citations (Scopus)


Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56bright CD16dim/ - and CD56dim CD16+, respectively. In this review, we will focus on the CD56bright NK cell subset. These cells are numerically in the minority in peripheral blood but constitute the majority of NK cells in secondary lymphoid tissues. They are abundant cytokine producers but are only weakly cytotoxic before activation. Recent data suggest that under certain conditions, they have immunoregulatory properties, and that they are probably immediate precursors of CD56dim NK cells. CD56 bright NK cell percentages are expanded or reduced in a certain number of diseases, but the significance of these variations is not yet clear.

Original languageEnglish
Pages (from-to)458-465
Number of pages8
Issue number4
Publication statusPublished - Apr 2009


  • CD56
  • Immunoregulation
  • Natural killer cells


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