CaSiAn: A calcium signaling analyzer tool

Mahsa Moein; Kamil Grzyb; Teresa Gonçalves Martins; Shinya Komoto; Francesca Peri; Alexander D. Crawford; Aymeric Fouquier D'Herouel; Alexander Skupin

doi:10.1093/bioinformatics/bty281

CaSiAn: A calcium signaling analyzer tool

Mahsa Moein, Kamil Grzyb, Teresa Gonçalves Martins, Shinya Komoto, Francesca Peri, Alexander D. Crawford, Aymeric Fouquier D'Herouel, Alexander Skupin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

Summary: Ca²⁺ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca²⁺ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca²⁺ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.

Original language	English
Pages (from-to)	3052-3054
Number of pages	3
Journal	Bioinformatics
Volume	34
Issue number	17
DOIs	https://doi.org/10.1093/bioinformatics/bty281
Publication status	Published - 1 Sept 2018
Externally published	Yes

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title = "CaSiAn: A calcium signaling analyzer tool",

abstract = "Summary: Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.",

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doi = "10.1093/bioinformatics/bty281",

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T2 - A calcium signaling analyzer tool

AU - Moein, Mahsa

AU - Grzyb, Kamil

AU - Gonçalves Martins, Teresa

AU - Komoto, Shinya

AU - Peri, Francesca

AU - Crawford, Alexander D.

AU - D'Herouel, Aymeric Fouquier

AU - Skupin, Alexander

PY - 2018/9/1

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N2 - Summary: Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.

AB - Summary: Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.

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CaSiAn: A calcium signaling analyzer tool

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