Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Shubhra Acharya, Andrew I. Lumley, Yvan Devaux*, Ibrahim Boussaad, Sarah Nickels, Marek Ostaszewski, Armin Rauschenberger, Stefano Sapienza, Carlos Vega, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Katy Beaumont, Camille Bellora, Jessica Calmes, Gessica ContesottoDaniela Esteves, Guy Fagherazzi, Jean Yves Ferrand, Jérôme Graas, Anne Marie Hanff, Estelle Henry, Alexander Hundt, Sonja Jónsdóttir, Pauline Lambert, Victoria Lorentz, Paula Cristina Lupu, Guilherme Marques, Deborah Mcintyre, Chouaib Mediouni, Myriam Menster, Fozia Noor, Magali Perquin, Rosalina Ramos Lima, Estelle Sandt, Margaux Schmitt, Amir Sharify, Kate Sokolowska, Hermann Thien, Johanna Trouet, Olena Tsurkalenko, Michel Vaillant, Mesele Valenti, Guy Berchem, Laure Pauly, Michel Mittelbronn, NCER-PD Consortium, Ulf Nehrbass

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results: We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion: Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.

Original languageEnglish
Article number33
Pages (from-to)33
JournalBMC Neuroscience
Volume25
Issue number1
DOIs
Publication statusPublished - 8 Jul 2024

Keywords

  • Cardiovascular health
  • Comorbidities
  • Parkinson’s disease
  • Sex-differences

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