TY - JOUR
T1 - Cardiovascular history and risk of idiopathic Parkinson’s disease
T2 - a cross-sectional observational study
AU - Acharya, Shubhra
AU - Lumley, Andrew I.
AU - Devaux, Yvan
AU - Boussaad, Ibrahim
AU - Nickels, Sarah
AU - Ostaszewski, Marek
AU - Rauschenberger, Armin
AU - Sapienza, Stefano
AU - Vega, Carlos
AU - Klucken, Jochen
AU - Krüger, Rejko
AU - Pauly, Claire
AU - Pavelka, Lukas
AU - Acharya, Geeta
AU - Aguayo, Gloria
AU - Alexandre, Myriam
AU - Beaumont, Katy
AU - Bellora, Camille
AU - Calmes, Jessica
AU - Contesotto, Gessica
AU - Esteves, Daniela
AU - Fagherazzi, Guy
AU - Ferrand, Jean Yves
AU - Graas, Jérôme
AU - Hanff, Anne Marie
AU - Henry, Estelle
AU - Hundt, Alexander
AU - Jónsdóttir, Sonja
AU - Lambert, Pauline
AU - Lorentz, Victoria
AU - Lupu, Paula Cristina
AU - Marques, Guilherme
AU - Mcintyre, Deborah
AU - Mediouni, Chouaib
AU - Menster, Myriam
AU - Noor, Fozia
AU - Perquin, Magali
AU - Lima, Rosalina Ramos
AU - Sandt, Estelle
AU - Schmitt, Margaux
AU - Sharify, Amir
AU - Sokolowska, Kate
AU - Thien, Hermann
AU - Trouet, Johanna
AU - Tsurkalenko, Olena
AU - Vaillant, Michel
AU - Valenti, Mesele
AU - Berchem, Guy
AU - Pauly, Laure
AU - Mittelbronn, Michel
AU - NCER-PD Consortium
AU - Nehrbass, Ulf
N1 - Funding
This work has been funded by grants from the Fonds National de la Recherche (FNR) of Luxembourg to S.A. (grant #AFR14566210) and to Y.D. (C14/BM/8225223, C17/BM/11613033, COVID-19/2020-1/14719577/miRCOVID), from the Ministry of Higher Education and Research of Luxembourg, and from the Heart Foundation—Daniel Wagner.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/7/8
Y1 - 2024/7/8
N2 - Background: Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results: We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion: Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.
AB - Background: Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results: We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion: Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.
KW - Cardiovascular health
KW - Comorbidities
KW - Parkinson’s disease
KW - Sex-differences
UR - http://www.scopus.com/inward/record.url?scp=85198059411&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/38977971/
U2 - 10.1186/s12868-024-00875-y
DO - 10.1186/s12868-024-00875-y
M3 - Article
C2 - 38977971
AN - SCOPUS:85198059411
SN - 1471-2202
VL - 25
SP - 33
JO - BMC Neuroscience
JF - BMC Neuroscience
IS - 1
M1 - 33
ER -