TY - JOUR
T1 - Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction
AU - Bousquenaud, Mélanie
AU - Maskali, Fatiha
AU - Poussier, Sylvain
AU - Zangrando, Jennifer
AU - Marie, Pierre Yves
AU - Boutley, Henri
AU - Fay, Renaud
AU - Karcher, Gilles
AU - Wagner, Daniel R.
AU - Devaux, Yvan
PY - 2013
Y1 - 2013
N2 - Background: Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography. Methods: Wistar rats were subjected to coronary ligation and randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; n = 8) or CADO with 8-sulfophenyltheophilline, an antagonist of adenosine receptors (8-SPT; n = 8). Results: After 2 months, control rats exhibited left ventricular remodelling, with increased end-diastolic volume and decreased ejection fraction. Left ventricular remodelling was not significantly inhibited by CADO. Segmental contractility, as assessed by the change in myocardial thickening after 2 months, was improved in CADO rats compared to control rats (+1.6% ± 0.8% vs. -2.3% ± 0.8%, p < 0.001). This improvement was significant in border (+5.6% ± 0.8% vs. +1.5% ± 0.8%, p < 0.001) and remote (-4.0% ± 1.0% vs. -10.4% ± 1.3%, p < 0.001) segments, but absent in MI segments. Histological analyses revealed that CADO reduced fibrosis, cardiomyocyte hypertrophy and apoptosis. Protective effects of CADO were blunted by 8-SPT. Conclusion: Long-term administration of adenosine protects the left ventricle from contractile dysfunction following MI.
AB - Background: Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography. Methods: Wistar rats were subjected to coronary ligation and randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; n = 8) or CADO with 8-sulfophenyltheophilline, an antagonist of adenosine receptors (8-SPT; n = 8). Results: After 2 months, control rats exhibited left ventricular remodelling, with increased end-diastolic volume and decreased ejection fraction. Left ventricular remodelling was not significantly inhibited by CADO. Segmental contractility, as assessed by the change in myocardial thickening after 2 months, was improved in CADO rats compared to control rats (+1.6% ± 0.8% vs. -2.3% ± 0.8%, p < 0.001). This improvement was significant in border (+5.6% ± 0.8% vs. +1.5% ± 0.8%, p < 0.001) and remote (-4.0% ± 1.0% vs. -10.4% ± 1.3%, p < 0.001) segments, but absent in MI segments. Histological analyses revealed that CADO reduced fibrosis, cardiomyocyte hypertrophy and apoptosis. Protective effects of CADO were blunted by 8-SPT. Conclusion: Long-term administration of adenosine protects the left ventricle from contractile dysfunction following MI.
KW - Adenosine
KW - Contractility
KW - Gated cardiac positron emission tomography
KW - Left ventricular remodelling
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=84887307074&partnerID=8YFLogxK
U2 - 10.1186/2191-219X-3-65
DO - 10.1186/2191-219X-3-65
M3 - Article
AN - SCOPUS:84887307074
SN - 2191-219X
VL - 3
SP - 1
EP - 10
JO - EJNMMI Research
JF - EJNMMI Research
IS - 1
M1 - 65
ER -