Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction

Mélanie Bousquenaud, Fatiha Maskali, Sylvain Poussier, Jennifer Zangrando, Pierre Yves Marie, Henri Boutley, Renaud Fay, Gilles Karcher, Daniel R. Wagner, Yvan Devaux*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Background: Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography. Methods: Wistar rats were subjected to coronary ligation and randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; n = 8) or CADO with 8-sulfophenyltheophilline, an antagonist of adenosine receptors (8-SPT; n = 8). Results: After 2 months, control rats exhibited left ventricular remodelling, with increased end-diastolic volume and decreased ejection fraction. Left ventricular remodelling was not significantly inhibited by CADO. Segmental contractility, as assessed by the change in myocardial thickening after 2 months, was improved in CADO rats compared to control rats (+1.6% ± 0.8% vs. -2.3% ± 0.8%, p < 0.001). This improvement was significant in border (+5.6% ± 0.8% vs. +1.5% ± 0.8%, p < 0.001) and remote (-4.0% ± 1.0% vs. -10.4% ± 1.3%, p < 0.001) segments, but absent in MI segments. Histological analyses revealed that CADO reduced fibrosis, cardiomyocyte hypertrophy and apoptosis. Protective effects of CADO were blunted by 8-SPT. Conclusion: Long-term administration of adenosine protects the left ventricle from contractile dysfunction following MI.

Original languageEnglish
Article number65
Pages (from-to)1-10
Number of pages10
JournalEJNMMI Research
Volume3
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Adenosine
  • Contractility
  • Gated cardiac positron emission tomography
  • Left ventricular remodelling
  • Myocardial infarction

Fingerprint

Dive into the research topics of 'Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction'. Together they form a unique fingerprint.

Cite this