TY - JOUR
T1 - Cardiometabolic risk
T2 - Leg fat is protective during childhood
AU - Samouda, Hanen
AU - De Beaufort, Carine
AU - Stranges, Saverio
AU - Hirsch, Marco
AU - Van Nieuwenhuyse, Jean Paul
AU - Dooms, Georges
AU - Gilson, Georges
AU - Keunen, Olivier
AU - Leite, Sonia
AU - Vaillant, Michel
AU - Lair, Marie Lise
AU - Dadoun, Frédéric
N1 - Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background: Childhood obesity is associated with early cardiometabolic risk (CMR), increased risk of adulthood obesity, and worse health outcomes. Leg fat mass (LFM) is protective beyond total fat mass (TFM) in adults. However, the limited evidence in children remains controversial. Objective: We investigated the relationship between LFM and CMR factors in youth. Subjects: A total of 203 overweight/obese children, 7-17-yr-old, followed in the Pediatric Clinic, Luxembourg. Methods: TFM and LFM by dual energy x-ray absorptiometry and a detailed set of CMR markers were analyzed. Results: After TFM, age, sex, body mass index (BMI) Z-score, sexual maturity status, and physical activity adjustments, negative significant partial correlations were shown between LFM and homeostasis model assessment of insulin resistance (HOMA) (variance explained: 6.05% by LFM; 7.18% by TFM), fasting insulin (variance explained: 5.71% by LFM; 6.97% by TFM), triglycerides (variance explained: 3.96% by LFM; 2.76% by TFM), systolic blood pressure (variance explained: 2.68% by LFM; 4.33% by TFM), C-reactive protein (variance explained: 2.31% by LFM; 4.28% by TFM), and resistin (variance explained: 2.16% by LFM; 3.57% by TFM). Significant positive partial correlations were observed between LFM and high-density lipoprotein (HDL) cholesterol (variance explained: 4.16% by LFM) and adiponectin (variance explained: 3.09% by LFM) (p-value < 0.05 and p-value < 0.001). In order to adjust for multiple testing, Benjamini-Hochberg method was applied and the adjusted significance level was determined for each analysis. LFM remained significant in the aforementioned models predicting HOMA, fasting insulin, triglycerides, and HDL cholesterol (Benjamini and Hochberg corrected p-value < 0.01). Conclusions: LFM is protective against CMR in children, at least in terms of insulin resistance and adverse blood lipid profiles.
AB - Background: Childhood obesity is associated with early cardiometabolic risk (CMR), increased risk of adulthood obesity, and worse health outcomes. Leg fat mass (LFM) is protective beyond total fat mass (TFM) in adults. However, the limited evidence in children remains controversial. Objective: We investigated the relationship between LFM and CMR factors in youth. Subjects: A total of 203 overweight/obese children, 7-17-yr-old, followed in the Pediatric Clinic, Luxembourg. Methods: TFM and LFM by dual energy x-ray absorptiometry and a detailed set of CMR markers were analyzed. Results: After TFM, age, sex, body mass index (BMI) Z-score, sexual maturity status, and physical activity adjustments, negative significant partial correlations were shown between LFM and homeostasis model assessment of insulin resistance (HOMA) (variance explained: 6.05% by LFM; 7.18% by TFM), fasting insulin (variance explained: 5.71% by LFM; 6.97% by TFM), triglycerides (variance explained: 3.96% by LFM; 2.76% by TFM), systolic blood pressure (variance explained: 2.68% by LFM; 4.33% by TFM), C-reactive protein (variance explained: 2.31% by LFM; 4.28% by TFM), and resistin (variance explained: 2.16% by LFM; 3.57% by TFM). Significant positive partial correlations were observed between LFM and high-density lipoprotein (HDL) cholesterol (variance explained: 4.16% by LFM) and adiponectin (variance explained: 3.09% by LFM) (p-value < 0.05 and p-value < 0.001). In order to adjust for multiple testing, Benjamini-Hochberg method was applied and the adjusted significance level was determined for each analysis. LFM remained significant in the aforementioned models predicting HOMA, fasting insulin, triglycerides, and HDL cholesterol (Benjamini and Hochberg corrected p-value < 0.01). Conclusions: LFM is protective against CMR in children, at least in terms of insulin resistance and adverse blood lipid profiles.
KW - Cardiometabolic risk
KW - DXA
KW - Fat mass
KW - Leg fat
KW - Visceral fat
UR - http://www.scopus.com/inward/record.url?scp=84931068379&partnerID=8YFLogxK
U2 - 10.1111/pedi.12292
DO - 10.1111/pedi.12292
M3 - Article
C2 - 26083149
AN - SCOPUS:84931068379
SN - 1399-543X
VL - 17
SP - 300
EP - 308
JO - Pediatric Diabetes
JF - Pediatric Diabetes
IS - 4
ER -