Cardiac Period 2 in myocardial ischemia: Clinical implications of a light dependent protein

Stephanie Bonney, Kelly Hughes, Patrick N. Harter, Michel Mittelbronn, Lori Walker, Tobias Eckle*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

24 Citations (Scopus)

Abstract

Since the onset of myocardial infarction and stroke has distinct circadian patterns, the disruption of circadian rhythms may contribute to cardiovascular disease. A recent clinical study, reporting that the severity of myocardial ischemia depends on the time-of-day when ischemia occurs, highlights the impact of circadian rhythms on cardiovascular disease. In support of these observations, we found a cardioprotective role of the circadian rhythm protein Period 2 (Per2) during myocardial ischemia in mice. In these studies, exposing mice to daylight induced cardiac Per2, which was associated with protection from myocardial ischemia. Recent epidemiological studies found sunlight to be the dominant regulator of the human circadian rhythm, suggesting sunlight cycles are critical for maintaining a healthy cardiovascular system. However, the impact of circadian rhythm proteins on human disease remains unclear. This current review aims to make a link to current and future clinical practice by targeting cardiac Per2.

Original languageEnglish
Pages (from-to)667-671
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume45
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Adenosine
  • Adora2b
  • Cardiac metabolism
  • Cardiovascular disease
  • Circadian rhythm
  • Heart ischemia
  • Ischemic preconditioning
  • Light therapy
  • Period 2

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