Caractérisation des souches de virus de l'hépatite B circulant en République centrafricaine : résultats préliminaires

Translated title of the contribution: Characterization of Hepatitis B virus strains from the Central African Republic: Preliminary results

C. Bekondi, C. M. Olinger, N. Boua, A. Talarmin, V. Venard, C. P. Muller, A. Le Faou*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Objectives: Genotyping of Hepatitis B virus (HBV) strains from patients in Central African Republic and comparison with results obtained in other African countries. Patients and methods: Sera were collected from patients admitted with symptoms of acute or chronic hepatitis to the "Hôpital de l'Amitié de Bangui", Central African Republic (CAR). The complete sequence of preS2/S gene has been defined for determining genotypes. Results: Hundred and ninety-six sera were collected from 112 men and 84 women. Ninety-two percent of patients had contact with HBV (anti-HBc postitive) and the HBsAg prevalence was about 62%. HBV DNA was detected in 66% of HBsAg positive sera. No HBV-DNA was evidenced among patients with negative HBsAg. Ninety-three percent of the HBV strains belonged to genotype E; one (3.4%) belonged to genotype A1, and one (3.4%) belonged to genotype D. Conclusions: The high prevalence of HBV infection in the studied population is due to their recruitment. The genotype E is predominant in CAR and the intragroup variability of HBV genotype E reached only 1.8%. Genotypes A and D were less common in CAR their presence may be explained by importation.

Translated title of the contributionCharacterization of Hepatitis B virus strains from the Central African Republic: Preliminary results
Original languageFrench
Pages (from-to)310-313
Number of pages4
JournalPathologie Biologie
Volume56
Issue number5
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Central African Republic
  • Genotype E
  • HBV
  • preS2/S region

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